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    il-12-antibody-ab124635.pdf

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Immunology Innate Immunity Cytokines Interleukins
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Anti-IL-12 antibody (ab124635)

  • Datasheet
  • SDS
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL-12 antibody (ab124635)

    Key features and details

    • Goat polyclonal to IL-12
    • Suitable for: IHC-P
    • Reacts with: Human
    • Isotype: IgG

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    Overview

    • Product name

      Anti-IL-12 antibody
      See all IL-12 primary antibodies
    • Description

      Goat polyclonal to IL-12
    • Host species

      Goat
    • Specificity

      ab124635 was raised against a synthetic peptide from human IL12A / p35
    • Tested applications

      Suitable for: IHC-Pmore details
    • Species reactivity

      Reacts with: Human
      Predicted to work with: Dog, Pig
    • Immunogen

      Synthetic peptide corresponding to Human IL-12.

    • Positive control

      • Human intestine (Paneth cells) tissue.
    • General notes

      The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

      If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

    Properties

    • Form

      Liquid
    • Storage instructions

      Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
    • Storage buffer

      pH: 7.30
      Preservative: 0.02% Sodium azide
      Constituents: 99% Tris buffered saline, 0.5% BSA
    • Concentration information loading...
    • Purity

      Protein G purified
    • Clonality

      Polyclonal
    • Isotype

      IgG
    • Research areas

      • Immunology
      • Innate Immunity
      • Cytokines
      • Interleukins
      • Cancer
      • Invasion/microenvironment
      • Angiogenesis
      • Angiogenic inhibitory factors
      • Cancer
      • Tumor immunology
      • Cytokines
      • Interleukins

    Associated products

    • Isotype control

      • Goat IgG, polyclonal - Isotype Control (ab37373)
    • Recombinant Protein

      • Recombinant human IL-12 p70 protein (Active) (ab259418)
      • Recombinant mouse IL-12 protein (Active) (ab259419)

    Applications

    The Abpromise guarantee

    Our Abpromise guarantee covers the use of ab124635 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    IHC-P
    Use a concentration of 3.75 µg/ml.
    Notes
    IHC-P
    Use a concentration of 3.75 µg/ml.

    Target

    • Function

      Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC.
    • Sequence similarities

      Belongs to the IL-6 superfamily.
    • Cellular localization

      Secreted.
    • Target information above from: UniProt accession P29459 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 3592 Human
      • Entrez Gene: 3593 Human
      • Omim: 161560 Human
      • Omim: 161561 Human
      • SwissProt: P29459 Human
      • SwissProt: P29460 Human
      • Unigene: 673 Human
      • Alternative names

        • CLMF antibody
        • CLMF p35 antibody
        • CLMF p40 antibody
        • CLMF1 antibody
        • CLMF2 antibody
        • Cytotoxic lymphocyte maturation factor 1, p35 antibody
        • Cytotoxic lymphocyte maturation factor 2 antibody
        • Cytotoxic lymphocyte maturation factor 35 kDa subunit antibody
        • Cytotoxic lymphocyte maturation factor 40 kDa subunit antibody
        • IL 12A antibody
        • IL 2 subunit p40 antibody
        • IL-12 subunit p35 antibody
        • IL-12A antibody
        • IL-12B antibody
        • IL12 antibody
        • IL12, p35 subunit antibody
        • IL12, subunit p40 antibody
        • IL12A antibody
        • IL12A_HUMAN antibody
        • IL12B antibody
        • IL35 subunit antibody
        • Interleukin 12 alpha chain antibody
        • Interleukin 12 beta chain antibody
        • Interleukin 12 subunit beta antibody
        • Interleukin 12, p40 antibody
        • Interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) antibody
        • Interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) antibody
        • Interleukin 12B antibody
        • Interleukin-12 subunit alpha antibody
        • Natural killer cell stimulatory factor 1, 35 kD subunit antibody
        • natural killer cell stimulatory factor 2 antibody
        • Natural killer cell stimulatory factor, 40 kD subunit antibody
        • NF cell stimulatory factor chain 1 antibody
        • NFSK antibody
        • NK cell stimulatory factor chain 1 antibody
        • NK cell stimulatory factor chain 2 antibody
        • NKSF antibody
        • NKSF1 antibody
        • NKSF2 antibody
        • P35 antibody
        see all

      Images

      • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL-12 antibody (ab124635)
        Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL-12 antibody (ab124635)

        ab124635, at 3.75µg/ml, staining IL-12 in formalin-fixed, paraffin-embedded Human intestine (paneth cells) tissue by Immunohistochemistry.

      Protocols

      • Immunohistochemistry protocols

      Click here to view the general protocols

      Datasheets and documents

      • SDS download

      • Datasheet download

        Download

      References (1)

      Publishing research using ab124635? Please let us know so that we can cite the reference in this datasheet.

      ab124635 has been referenced in 1 publication.

      • Brcic L  et al. Immune cell landscape in therapy-naïve squamous cell and adenocarcinomas of the lung. Virchows Arch 472:589-598 (2018). PubMed: 29520483

      Customer reviews and Q&As

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