Anti-IL-12RB2 antibody (ab198833)
Key features and details
- Rabbit polyclonal to IL-12RB2
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-IL-12RB2 antibody
See all IL-12RB2 primary antibodies -
Description
Rabbit polyclonal to IL-12RB2 -
Host species
Rabbit -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human -
Immunogen
Synthetic peptide corresponding to Human IL-12RB2 (internal sequence). NP_001550.
Database link: Q99665 -
Positive control
- Human gastric cancer tissue and Human thyroid cancer tissue
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General notes
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 49% PBS, 50% Glycerol (glycerin, glycerine) -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
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Related Products
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab198833 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P |
1/50 - 1/200.
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Notes |
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IHC-P
1/50 - 1/200. |
Target
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Function
Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production. -
Tissue specificity
Isoform 2 is expressed at similar levels in both naive and activated T-cells. -
Sequence similarities
Belongs to the type I cytokine receptor family. Type 2 subfamily.
Contains 5 fibronectin type-III domains. -
Developmental stage
Maximum levels in Th1 cells between day 3 and day 8 of activation. -
Domain
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation. -
Post-translational
modificationsOn IL12 binding, phosphorylated on C-terminal tyrosine residues by JAK2. Phosphorylation on Tyr-800 is required for STAT4 binding and activation, and for SOCS3 binding. -
Cellular localization
Membrane. - Information by UniProt
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Database links
- Entrez Gene: 3595 Human
- Omim: 601642 Human
- SwissProt: Q99665 Human
- Unigene: 479347 Human
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Alternative names
- I12R2_HUMAN antibody
- IL-12 receptor subunit beta-2 antibody
- IL-12R subunit beta-2 antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab198833 has not yet been referenced specifically in any publications.