Key features and details
- Rabbit polyclonal to IL-12RB2
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-IL-12RB2 antibody
See all IL-12RB2 primary antibodies
DescriptionRabbit polyclonal to IL-12RB2
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Human
Recombinant fragment corresponding to Human IL-12RB2 aa 323-665.
- 293T, H1299, HeLaS3, Molt 4, Raji; A431 or HepG2 whole cell lysate (ab7900)
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In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage bufferpH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 10% Glycerol (glycerin, glycerine)
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab96097 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/3000. Predicted molecular weight: 97 kDa.|
FunctionReceptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production.
Tissue specificityIsoform 2 is expressed at similar levels in both naive and activated T-cells.
Sequence similaritiesBelongs to the type I cytokine receptor family. Type 2 subfamily.
Contains 5 fibronectin type-III domains.
Developmental stageMaximum levels in Th1 cells between day 3 and day 8 of activation.
DomainThe WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.
modificationsOn IL12 binding, phosphorylated on C-terminal tyrosine residues by JAK2. Phosphorylation on Tyr-800 is required for STAT4 binding and activation, and for SOCS3 binding.
- Information by UniProt
- I12R2_HUMAN antibody
- IL-12 receptor subunit beta-2 antibody
- IL-12R subunit beta-2 antibody
ab96097 has been referenced in 1 publication.
- Hackett TL et al. Fibroblast signal transducer and activator of transcription 4 drives cigarette smoke-induced airway fibrosis. Am J Respir Cell Mol Biol 51:830-9 (2014). PubMed: 24922586