Overview

  • Product name

    Anti-IL-13 receptor alpha 1 antibody [GM1E7]
    See all IL-13 receptor alpha 1 primary antibodies
  • Description

    Mouse monoclonal [GM1E7] to IL-13 receptor alpha 1
  • Host species

    Mouse
  • Specificity

    The antibody recognises IL-13 Receptor 1 alpha transiently expressed on the cell surface of transfected BOSC cells as well as the native protein on monocytes.
  • Tested applications

    Suitable for: Flow Cytmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    cDNA of human IL-13R alpha 1 chain extracellular domain

Properties

Applications

Our Abpromise guarantee covers the use of ab39418 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt
  • Application notes
    Flow Cyt: Use 25µl of a 2.5 µg/ml concentration.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function

      Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity.
    • Tissue specificity

      Ubiquitous. Highest levels in heart, liver, skeletal muscle and ovary; lowest levels in brain, lung and kidney. Also found in B-cells, T-cells and endothelial cells.
    • Sequence similarities

      Belongs to the type I cytokine receptor family. Type 5 subfamily.
    • Domain

      The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
      The box 1 motif is required for JAK interaction and/or activation.
    • Cellular localization

      Membrane.
    • Information by UniProt
    • Database links

    • Alternative names

      • bB128O4.2.1 (interleukin 13 receptor, alpha 1) antibody
      • Cancer/testis antigen 19 antibody
      • CD213a1 antibody
      • CD213A1 Antigen antibody
      • CT 19 antibody
      • CT19 antibody
      • I13R1_HUMAN antibody
      • IL 13 receptor subunit alpha 1 antibody
      • IL 13R alpha 1 antibody
      • IL 13R subunit alpha 1 antibody
      • IL 13Ra antibody
      • IL 13RA1 antibody
      • IL-13 receptor subunit alpha-1 antibody
      • IL-13R subunit alpha-1 antibody
      • IL-13R-alpha-1 antibody
      • IL-13RA1 antibody
      • IL13 receptor alpha 1 chain antibody
      • IL13R antibody
      • IL13RA antibody
      • Il13ra1 antibody
      • Interleukin 13 receptor alpha 1 antibody
      • Interleukin 13 receptor alpha 1 chain antibody
      • interleukin 13 receptor subunit alpha 1 antibody
      • Interleukin-13 receptor subunit alpha-1 antibody
      • NR 4 antibody
      • NR4 antibody
      see all

    Images

    • Specificity testing of ab39418. BOSC cells were transiently transfected with an expression vector encoding either the extracellular domain of IL-13Rα1 or an irrelevant protein. Expression of the constructs was tested with an anti-tag monoclonal antibody (B, green curves), an irrelevant monoclonal antibody served as negative control (bluecurves). For specificity testing (A), purified ab39418 was tested on both the IL-13Rα1 (red curve) and the irrelevant protein trans-fectants (green curve). A posi-tive signal was obtained only with IL-13Rα1 transfected cells.

    References

    ab39418 has not yet been referenced specifically in any publications.

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