Overview

  • Product name

    Anti-IL-15RA antibody [RM0103-6C38]
    See all IL-15RA primary antibodies
  • Description

    Rat monoclonal [RM0103-6C38] to IL-15RA
  • Host species

    Rat
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Mouse
  • Immunogen

    Recombinant fragment corresponding to Mouse IL-15RA.

Properties

Applications

Our Abpromise guarantee covers the use of ab86486 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notes
    WB: 1/500 - 1/1000. Predicted molecular weight: 28 kDa (isoform 1).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function

      Receptor for interleukin-15. Expression of different isoforms may alter or interfere with signal transduction. Isoform 5, isoform 6, isoform 7 and isoform 8 do not bind IL15. Signal transduction involves STAT3, STAT5, STAT6, JAK2 (By similarity) and SYK.
    • Tissue specificity

      Isoform 1, isoform 3, isoform 4, isoform 5, isoform 6, isoform 7, isoform 8 and isoform 9 are widely expressed. Expressed in fetal brain with higher expression in the hippocampus and cerebellum than in cortex and thalamus. Higher levels of soluble sIL-15RA form in comparison with membrane-bound forms is present in all brain structures.
    • Sequence similarities

      Contains 1 Sushi (CCP/SCR) domain.
    • Post-translational
      modifications

      A soluble form (sIL-15RA) arises from proteolytic shedding of the membrane-anchored receptor. The cleavage involves ADAM17/TACE (By similarity). It also binds IL-15 and thus interferes with IL-15 binding to the membrane receptor.
      Phosphorylated by activated SYK.
      N-glycosylated and O-glycosylated.
    • Cellular localization

      Secreted > extracellular space; Membrane. Nucleus membrane. Mainly found associated with the nuclear membrane and Endoplasmic reticulum membrane. Golgi apparatus membrane. Cytoplasmic vesicle membrane. Membrane. Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.
    • Information by UniProt
    • Database links

    • Alternative names

      • AA690181 antibody
      • CD215 antibody
      • I15RA_HUMAN antibody
      • IL 15R alpha antibody
      • IL-15 receptor subunit alpha antibody
      • IL-15R-alpha antibody
      • IL-15RA antibody
      • Il15ra antibody
      • Interleukin 15 receptor alpha antibody
      • Interleukin 15 receptor subunit alpha antibody
      • MGC104179 antibody
      • sIL-15 receptor subunit alpha antibody
      • sIL-15R-alpha antibody
      • sIL-15RA antibody
      • Soluble interleukin 15 receptor subunit alpha antibody
      • Soluble interleukin-15 receptor subunit alpha antibody
      see all

    References

    This product has been referenced in:

    • Takashima A  et al. Uterine natural killer cells severely decrease in number at gestation day 6 in mice. Biol Reprod 89:101 (2013). WB ; Mouse . Read more (PubMed: 24025738) »
    • Chenoweth MJ  et al. IL-15 can signal via IL-15Ra, JNK, and NF-?B to drive RANTES production by myeloid cells. J Immunol 188:4149-57 (2012). Blocking ; Mouse . Read more (PubMed: 22447977) »
    See all 2 Publications for this product

    Customer reviews and Q&As

    Answer

    Thank you for your phone call. Unfortunately, I was unable to obtain any more specific information about the immunogen other than that it is the extracellular domain (33-205aa) of mouse IL-15R alpha (Q60819). I hope this helps, please let me know if you need any additional information or assistance.

    Read More

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