Key features and details
- Rat monoclonal [RM0103-6C38] to IL-15RA
- Suitable for: WB
- Reacts with: Mouse
- Isotype: IgG2a
Product nameAnti-IL-15RA antibody [RM0103-6C38]
See all IL-15RA primary antibodies
DescriptionRat monoclonal [RM0103-6C38] to IL-15RA
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Mouse
Recombinant fragment corresponding to Mouse IL-15RA.
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage bufferConstituent: PBS
Concentration information loading...
Purification notesThe IgG fraction of culture supernatant was purified by protein A/G affinity chromatography and 0.2µm filtered.
Our Abpromise guarantee covers the use of ab86486 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionReceptor for interleukin-15. Expression of different isoforms may alter or interfere with signal transduction. Isoform 5, isoform 6, isoform 7 and isoform 8 do not bind IL15. Signal transduction involves STAT3, STAT5, STAT6, JAK2 (By similarity) and SYK.
Tissue specificityIsoform 1, isoform 3, isoform 4, isoform 5, isoform 6, isoform 7, isoform 8 and isoform 9 are widely expressed. Expressed in fetal brain with higher expression in the hippocampus and cerebellum than in cortex and thalamus. Higher levels of soluble sIL-15RA form in comparison with membrane-bound forms is present in all brain structures.
Sequence similaritiesContains 1 Sushi (CCP/SCR) domain.
modificationsA soluble form (sIL-15RA) arises from proteolytic shedding of the membrane-anchored receptor. The cleavage involves ADAM17/TACE (By similarity). It also binds IL-15 and thus interferes with IL-15 binding to the membrane receptor.
Phosphorylated by activated SYK.
N-glycosylated and O-glycosylated.
Cellular localizationSecreted > extracellular space; Membrane. Nucleus membrane. Mainly found associated with the nuclear membrane and Endoplasmic reticulum membrane. Golgi apparatus membrane. Cytoplasmic vesicle membrane. Membrane. Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.
- Information by UniProt
- AA690181 antibody
- CD215 antibody
- I15RA_HUMAN antibody
ab86486 has been referenced in 2 publications.
- Takashima A et al. Uterine natural killer cells severely decrease in number at gestation day 6 in mice. Biol Reprod 89:101 (2013). WB ; Mouse . PubMed: 24025738
- Chenoweth MJ et al. IL-15 can signal via IL-15Ra, JNK, and NF-?B to drive RANTES production by myeloid cells. J Immunol 188:4149-57 (2012). Blocking ; Mouse . PubMed: 22447977