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    il-16-antibody-ab180792.pdf

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Immunology Innate Immunity Cytokines Interleukins
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Anti-IL-16 antibody (ab180792)

  • Datasheet
Submit a review Submit a question References (2)

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Immunocytochemistry/ Immunofluorescence - Anti-IL-16 antibody (ab180792)
  • Western blot - Anti-IL-16 antibody (ab180792)

Key features and details

  • Rabbit polyclonal to IL-16
  • Suitable for: WB, ICC/IF
  • Reacts with: Mouse, Rat, Human
  • Isotype: IgG

You may also be interested in

Protein
Recombinant human IL-16 protein (ab151838)

View more associated products

Overview

  • Product name

    Anti-IL-16 antibody
    See all IL-16 primary antibodies
  • Description

    Rabbit polyclonal to IL-16
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, ICC/IFmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Recombinant full length protein corresponding to Human IL-16 aa 1-305 (N terminal).
    Database link: Q14005

  • General notes

    Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

    Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

    We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

    In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

    We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

    Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

    Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: 49% PBS, 50% Glycerol
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Immunology
    • Innate Immunity
    • Cytokines
    • Interleukins

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
  • Positive Controls

    • Mouse brain tissue lysate - total protein (ab30151)
  • Recombinant Protein

    • Recombinant human IL-16 protein (ab151838)
  • Related Products

    • Jurkat whole cell lysate (ab30128)
    • Jurkat whole cell lysate (ab7899)
    • A549 whole cell lysate (ab7910)

Applications

Our Abpromise guarantee covers the use of ab180792 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/2000. Predicted molecular weight: 142 kDa.
ICC/IF Use at an assay dependent concentration.

Target

  • Function

    Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.
    Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane.
    Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.
  • Tissue specificity

    Isoform 3 is expressed in hemopoietic tissues, such as resting T-cells, but is undetectable during active T cell proliferation.
  • Sequence similarities

    Contains 4 PDZ (DHR) domains.
  • Post-translational
    modifications

    Isoform 3 is synthesized as a chemo-attractant inactive precursor in hemopoietic tissues and is proteolytically cleaved by caspase-3 to yield IL-16.
  • Cellular localization

    Cytoplasm; Cytoplasm. Nucleus and Secreted.
  • Target information above from: UniProt accession Q14005 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 3603 Human
    • Entrez Gene: 16170 Mouse
    • Entrez Gene: 116996 Rat
    • Omim: 603035 Human
    • SwissProt: Q14005 Human
    • SwissProt: O54824 Mouse
    • Unigene: 459095 Human
    • Unigene: 10137 Mouse
    • Unigene: 104665 Rat
    see all
  • Alternative names

    • HGNC:5980 antibody
    • HsT19289 antibody
    • IL-16 antibody
    • IL16 antibody
    • IL16_HUMAN antibody
    • Interleukin 16 precursor antibody
    • Interleukin-16 antibody
    • LCF antibody
    • Lymphocyte chemoattractant factor antibody
    • Neuronal interleukin 16 antibody
    • NIL16 antibody
    • prIL 16 antibody
    • PrIL16 antibody
    • Prointerleukin 16 antibody
    see all

Images

  • Immunocytochemistry/ Immunofluorescence - Anti-IL-16 antibody (ab180792)
    Immunocytochemistry/ Immunofluorescence - Anti-IL-16 antibody (ab180792)
    Immunocytochemistry/Immunofluorescence analysis of U2OS cells using ab180792. Blue DAPI for nuclear staining.
  • Western blot - Anti-IL-16 antibody (ab180792)
    Western blot - Anti-IL-16 antibody (ab180792)
    All lanes : Anti-IL-16 antibody (ab180792) at 1/500 dilution

    Lane 1 : A549 cell line extract
    Lane 2 : Jurkat cell line extract
    Lane 3 : Mouse brain extract

    Predicted band size: 142 kDa

Protocols

  • Immunocytochemistry & immunofluorescence protocols
  • Western blot protocols

Click here to view the general protocols

Datasheets and documents

    • Datasheet
  • References (2)

    Publishing research using ab180792? Please let us know so that we can cite the reference in this datasheet.

    ab180792 has been referenced in 2 publications.

    • Yang Z  et al. Overexpression of microRNA-34a Attenuates Proliferation and Induces Apoptosis in Pituitary Adenoma Cells via SOX7. Mol Ther Oncolytics 10:40-47 (2018). PubMed: 30109259
    • Yang H  et al. Diagnostic and prognostic value of serum interleukin-16 in patients with gastric cancer. Mol Med Rep 16:9143-9148 (2017). PubMed: 28990054

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