Overview

  • Product name

    Anti-IL-16 antibody [G11/II]
    See all IL-16 primary antibodies
  • Description

    Mouse monoclonal [G11/II] to IL-16
  • Host species

    Mouse
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant full length protein corresponding to Human IL-16.
    Database link: NP_004504.3

  • Positive control

    • Human Spleen tissue

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer

    pH: 7.20
    Preservative: 0.1% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity

    Affinity purified
  • Clonality

    Monoclonal
  • Clone number

    G11/II
  • Isotype

    IgG1
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab118611 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 5 µg/ml.

Target

  • Function

    Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.
    Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane.
    Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.
  • Tissue specificity

    Isoform 3 is expressed in hemopoietic tissues, such as resting T-cells, but is undetectable during active T cell proliferation.
  • Sequence similarities

    Contains 4 PDZ (DHR) domains.
  • Post-translational
    modifications

    Isoform 3 is synthesized as a chemo-attractant inactive precursor in hemopoietic tissues and is proteolytically cleaved by caspase-3 to yield IL-16.
  • Cellular localization

    Cytoplasm; Cytoplasm. Nucleus and Secreted.
  • Information by UniProt
  • Database links

  • Alternative names

    • HGNC:5980 antibody
    • HsT19289 antibody
    • IL-16 antibody
    • IL16 antibody
    • IL16_HUMAN antibody
    • Interleukin 16 precursor antibody
    • Interleukin-16 antibody
    • LCF antibody
    • Lymphocyte chemoattractant factor antibody
    • Neuronal interleukin 16 antibody
    • NIL16 antibody
    • prIL 16 antibody
    • PrIL16 antibody
    • Prointerleukin 16 antibody
    see all

Images

  • ab118611 at 5 &microg/ml staining IL-16 in Formalin-fixed, Paraffin-embedded Human Spleen tissue by Immunohistochemistry.

References

ab118611 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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