Key features and details
- Mouse monoclonal [G11/II] to IL-16
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG1
Product nameAnti-IL-16 antibody [G11/II]
See all IL-16 primary antibodies
DescriptionMouse monoclonal [G11/II] to IL-16
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Human
Recombinant full length protein corresponding to Human IL-16.
Database link: NP_004504.3
- Human Spleen tissue
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
Storage bufferpH: 7.20
Preservative: 0.1% Sodium azide
Constituent: 99% PBS
Concentration information loading...
Our Abpromise guarantee covers the use of ab118611 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||Use a concentration of 5 µg/ml.|
FunctionInterleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.
Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane.
Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.
Tissue specificityIsoform 3 is expressed in hemopoietic tissues, such as resting T-cells, but is undetectable during active T cell proliferation.
Sequence similaritiesContains 4 PDZ (DHR) domains.
modificationsIsoform 3 is synthesized as a chemo-attractant inactive precursor in hemopoietic tissues and is proteolytically cleaved by caspase-3 to yield IL-16.
Cellular localizationCytoplasm; Cytoplasm. Nucleus and Secreted.
- Information by UniProt
- HGNC:5980 antibody
- HsT19289 antibody
- IL-16 antibody
ab118611 has been referenced in 1 publication.
- Kawabata K et al. IL-16 expression is increased in the skin and sera of patients with systemic sclerosis. Rheumatology (Oxford) N/A:N/A (2019). PubMed: 31377804