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  1. Link

    il-17a-antibody-ab193955.pdf

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Immunology Innate Immunity Cytokines Interleukins
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Anti-IL-17A antibody (ab193955)

  • Datasheet
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Key features and details

  • Rabbit polyclonal to IL-17A
  • Reacts with: Mouse, Rat, Rabbit, Horse, Cow, Dog, Human, Pig
  • Isotype: IgG

Get better batch-to-batch reproducibility with a recombinant antibody

Product image
Anti-IL-17A antibody [EPR21776] (ab218013)
  • Research with confidence – consistent and reproducible results with every batch
  • Long-term and scalable supply – powered by recombinant technology for fast production
  • Success from the first experiment – confirmed specificity through extensive validation
  • Ethical standards compliant – production is animal-free

Overview

  • Product name

    Anti-IL-17A antibody
    See all IL-17A primary antibodies
  • Description

    Rabbit polyclonal to IL-17A
  • Host species

    Rabbit
  • Species reactivity

    Reacts with: Mouse, Rat, Rabbit, Horse, Cow, Dog, Human, Pig
  • Immunogen

    Recombinant full length protein corresponding to Cow IL-17A aa 1 to the C-terminus.
    Database link: Q687Y7

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
  • General notes

    Cross-reactivity determined in ELISA.

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    Preservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Immunology
    • Innate Immunity
    • Cytokines
    • Interleukins
    • Neuroscience
    • Processes

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)

Target

  • Function

    Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of the intracellular adhesion molecule-1 (ICAM-1) in fibroblasts.
  • Tissue specificity

    Restricted to activated memory T-cells.
  • Sequence similarities

    Belongs to the IL-17 family.
  • Post-translational
    modifications

    Found both in glycosylated and nonglycosylated forms.
  • Cellular localization

    Secreted.
  • Target information above from: UniProt accession Q16552 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 282863 Cow
    • Entrez Gene: 3605 Human
    • Entrez Gene: 16171 Mouse
    • Entrez Gene: 449530 Pig
    • Entrez Gene: 100339322 Rabbit
    • Entrez Gene: 301289 Rat
    • Omim: 603149 Human
    • SwissProt: Q687Y7 Cow
    • SwissProt: Q16552 Human
    • SwissProt: Q62386 Mouse
    • SwissProt: Q60I29 Pig
    • SwissProt: Q61453 Rat
    • Unigene: 41724 Human
    see all
  • Alternative names

    • CTLA 8 antibody
    • CTLA-8 antibody
    • CTLA8 antibody
    • cytotoxic T lymphocyte associated antigen 8 antibody
    • Cytotoxic T lymphocyte associated protein 8 antibody
    • Cytotoxic T lymphocyte associated serine esterase 8 antibody
    • Cytotoxic T-lymphocyte-associated antigen 8 antibody
    • IL 17 antibody
    • IL 17A antibody
    • IL-17 antibody
    • IL-17A antibody
    • IL17 antibody
    • IL17_HUMAN antibody
    • Il17a antibody
    • Interleukin 17 (cytotoxic T lymphocyte associated serine esterase 8) antibody
    • interleukin 17A antibody
    • Interleukin-17A antibody
    • interleukin17 antibody
    • Interleukin17A antibody
    • OTTHUMP00000016597 antibody
    • OTTMUSP00000046003 antibody
    see all

Protocols

  • Western blot protocols

Click here to view the general protocols

Datasheets and documents

  • Datasheet download

    Download

References (3)

Publishing research using ab193955? Please let us know so that we can cite the reference in this datasheet.

ab193955 has been referenced in 3 publications.

  • Cui C  et al. Propofol maintains Th17/Treg cell balance and reduces inflammation in rats with traumatic brain injury via the miR-145-3p/NFATc2/NF-?B axis. Int J Mol Med 48:N/A (2021). PubMed: 34036377
  • Yang J  et al. IL-1ß increases the expression of inflammatory factors in synovial fluid-derived fibroblast-like synoviocytes via activation of the NF-?B-mediated ERK-STAT1 signaling pathway. Mol Med Rep 20:4993-5001 (2019). PubMed: 31638264
  • Fu Z  et al. Hesperidin protects against IL-1ß-induced inflammation in human osteoarthritis chondrocytes. Exp Ther Med 16:3721-3727 (2018). PubMed: 30233731

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