Anti-IL-17A antibody (ab9565)
Key features and details
- Rabbit polyclonal to IL-17A
- Suitable for: IHC-P, ELISA, WB
- Reacts with: Human
- Isotype: unknown
Get better batch-to-batch reproducibility with a recombinant antibody
- Research with confidence – consistent and reproducible results with every batch
- Long-term and scalable supply – powered by recombinant technology for fast production
- Success from the first experiment – confirmed specificity through extensive validation
- Ethical standards compliant – production is animal-free
Overview
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Product name
Anti-IL-17A antibody
See all IL-17A primary antibodies -
Description
Rabbit polyclonal to IL-17A -
Host species
Rabbit -
Tested applications
Suitable for: IHC-P, ELISA, WBmore details -
Species reactivity
Reacts with: Human -
Immunogen
Recombinant full length protein corresponding to Human IL-17A. Highly pure (>98%) recombinant hIL-17 (human Interleukin-17)
Database link: Q16552 -
Positive control
- WB: Recombinant human IL-17A protein (ab9567).
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General notes
Although some customers have been successful in IHC we no longer batch test in this application.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Lyophilized:Reconstitute with 200µl of sterile water. Please note that if you receive this product in liquid form it has already been reconstituted as described and no further reconstitution is necessary. -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
unknown -
Light chain type
unknown -
Research areas
Associated products
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Compatible Secondaries
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Positive Controls
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab9565 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P | (2) |
Use at an assay dependent concentration. PubMed: 29390966
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ELISA |
Use at an assay dependent concentration.
Allows the detection of 0.2 - 0.4 ng/well of recombinant hIL-17 (assuming 100 µl/well antibody solution). |
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WB |
Use at an assay dependent concentration.
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Notes |
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IHC-P
Use at an assay dependent concentration. PubMed: 29390966 |
ELISA
Use at an assay dependent concentration. Allows the detection of 0.2 - 0.4 ng/well of recombinant hIL-17 (assuming 100 µl/well antibody solution). |
WB
Use at an assay dependent concentration. |
Target
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Function
Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of the intracellular adhesion molecule-1 (ICAM-1) in fibroblasts. -
Tissue specificity
Restricted to activated memory T-cells. -
Sequence similarities
Belongs to the IL-17 family. -
Post-translational
modificationsFound both in glycosylated and nonglycosylated forms. -
Cellular localization
Secreted. - Information by UniProt
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Database links
- Entrez Gene: 3605 Human
- Omim: 603149 Human
- SwissProt: Q16552 Human
- Unigene: 41724 Human
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Alternative names
- CTLA 8 antibody
- CTLA-8 antibody
- CTLA8 antibody
see all
Datasheets and documents
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Datasheet download
References (19)
ab9565 has been referenced in 19 publications.
- Montanaro M et al. The Paradox Effect of Calcification in Carotid Atherosclerosis: Microcalcification is Correlated with Plaque Instability. Int J Mol Sci 22:N/A (2021). PubMed: 33401449
- Orejudo M et al. Interleukin 17A Participates in Renal Inflammation Associated to Experimental and Human Hypertension. Front Pharmacol 10:1015 (2019). PubMed: 31572188
- Othman AA et al. Pharmacokinetics, Safety, and Tolerability of the Dual Inhibitor of Tumor Necrosis Factor-a and Interleukin 17A, ABBV-257, in Healthy Volunteers and Patients With Rheumatoid Arthritis. Clin Pharmacol Drug Dev 8:492-502 (2019). PubMed: 30156758
- Ding H et al. Upregulation of CD81 in trophoblasts induces an imbalance of Treg/Th17 cells by promoting IL-6 expression in preeclampsia. Cell Mol Immunol 16:302-312 (2019). PubMed: 30487550
- Li S et al. Tumor-associated neutrophils induce EMT by IL-17a to promote migration and invasion in gastric cancer cells. J Exp Clin Cancer Res 38:6 (2019). PubMed: 30616627