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    il-2-antibody-b-g5-ab47194.pdf

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Immunology Innate Immunity Cytokines Interleukins
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Anti-IL-2 antibody [B-G5] (ab47194)

  • Datasheet
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Key features and details

  • Mouse monoclonal [B-G5] to IL-2
  • Reacts with: Human
  • Isotype: IgG1

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Overview

  • Product name

    Anti-IL-2 antibody [B-G5]
    See all IL-2 primary antibodies
  • Description

    Mouse monoclonal [B-G5] to IL-2
  • Host species

    Mouse
  • Specificity

    This antibody is specific for both natural and recombinant IL2.
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Full length native protein (purified) corresponding to Human IL-2.
    Database link: P60568

  • Positive control

    • Purchase matching WB positive control:Recombinant human IL-2 protein
  • General notes

    Blocks IL2 induced proliferation on CTL-L2 murine cell line.

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing the problem with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation.

    One factor contributing to the crisis is the use of antibodies that are not suitable. This can lead to misleading results and the use of incorrect data informing project assumptions and direction. To help address this challenge, we have introduced an application and species grid on our primary antibody datasheets to make it easy to simplify identification of the right antibody for your needs.

    Learn more here.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.3
    Constituent: PBS
  • Concentration information loading...
  • Purity

    Ion Exchange Chromatography
  • Purification notes

    Sterile filtered through 0.22 µm and treated to remove endotoxins. Carrier and preservative free.
  • Clonality

    Monoclonal
  • Clone number

    B-G5
  • Myeloma

    x63-Ag8.653
  • Isotype

    IgG1
  • Research areas

    • Immunology
    • Innate Immunity
    • Cytokines
    • Interleukins

Associated products

  • Alternative Versions

    • Anti-IL-2 antibody [B-G5] - BSA and Azide free (ab269722)
  • Compatible Secondaries

    • Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (ab150113)
    • Goat Anti-Mouse IgG H&L (HRP) (ab205719)
  • Conjugation kits

    • PE / R-Phycoerythrin Conjugation Kit - Lightning-Link® (ab102918)
    • APC Conjugation Kit - Lightning-Link® (ab201807)
  • Isotype control

    • Mouse IgG1, kappa monoclonal [15-6E10A7] - Isotype Control (ab170190)
  • Recombinant Protein

    • Recombinant mouse IL-2 protein (ab9856)

Target

  • Function

    Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
  • Involvement in disease

    Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.
  • Sequence similarities

    Belongs to the IL-2 family.
  • Cellular localization

    Secreted.
  • Target information above from: UniProt accession P60568 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 3558 Human
    • Omim: 147680 Human
    • SwissProt: P60568 Human
    • Unigene: 89679 Human
    • Alternative names

      • Aldesleukin antibody
      • IL 2 antibody
      • IL-2 antibody
      • IL2 antibody
      • IL2_HUMAN antibody
      • Interleukin 2 antibody
      • Interleukin-2 antibody
      • interleukin2 antibody
      • Involved in regulation of T cell clonal expansion antibody
      • Lymphokine antibody
      • OTTHUMP00000164090 antibody
      • POIL2 antibody
      • T Cell Growth Factor antibody
      • T-cell growth factor antibody
      • TCGF antibody
      see all

    Protocols

    • Western blot protocols
    • Flow cytometry protocols

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download

    References (0)

    Publishing research using ab47194? Please let us know so that we can cite the reference in this datasheet.

    ab47194 has not yet been referenced specifically in any publications.

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