Anti-IL-2 Receptor alpha antibody [7D4] (Phycoerythrin) (ab24933)

Overview

  • Product name
    Anti-IL-2 Receptor alpha antibody [7D4] (Phycoerythrin)
    See all IL-2 Receptor alpha primary antibodies
  • Description
    Rat monoclonal [7D4] to IL-2 Receptor alpha (Phycoerythrin)
  • Host species
    Rat
  • Conjugation
    Phycoerythrin. Ex: 488nm, Em: 575nm
  • Specificity
    This antibody recognises low affinity IL-2 receptor alpha.
  • Tested applications
    Suitable for: Flow Cyt, IPmore details
  • Species reactivity
    Reacts with: Mouse
  • Immunogen

    Tissue, cells or virus corresponding to Mouse IL-2 Receptor alpha.

  • Epitope
    This antibody reacts with an epitope located between amino acids 125 and 212 of IL-2 receptor alpha.
  • Positive control
    • Cells from BALB/c spleen activated with PMA and ionomycin for Immunofluorescent staining with Flow Cytometric analysis.
  • General notes

     

    This antibody does not block the binding of IL-2 to CD25.

Properties

Applications

Our Abpromise guarantee covers the use of ab24933 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt Use 0.2µg for 106 cells.

ab154451 - Rat monoclonal IgM, is suitable for use as an isotype control with this antibody.

 

IP Use at an assay dependent concentration.

Target

  • Function
    Receptor for interleukin-2.
  • Involvement in disease
    Genetic variations in IL2RA are associated with susceptibility to diabetes mellitus insulin-dependent type 10 (IDDM10) [MIM:601942]. A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
  • Sequence similarities
    Contains 2 Sushi (CCP/SCR) domains.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Interleukin 2 receptor alpha chain antibody
    • CD25 antibody
    • CD25 antigen antibody
    • IDDM10 antibody
    • IL 2 receptor alpha subunit antibody
    • IL-2 receptor subunit alpha antibody
    • IL-2-RA antibody
    • IL-2R subunit alpha antibody
    • IL2 RA antibody
    • IL2 Receptor alpha antibody
    • IL2-RA antibody
    • IL2R antibody
    • IL2R, alpha chain antibody
    • IL2RA antibody
    • IL2RA_HUMAN antibody
    • IMD41 antibody
    • Interleukin 2 receptor alpha antibody
    • Interleukin 2 receptor antibody
    • Interleukin-2 receptor subunit alpha antibody
    • p55 antibody
    • t-cell growth factor receptor antibody
    • TAC antibody
    • TAC antigen antibody
    • TCGFR antibody
    see all

Images

  • Ab24933, at a concentration of 0.1µg for 106 cells, staining CD25 in cells from BALB/c spleen that had been activated by PMA (10 ng/ml) and ionomycin (400 ng/ml) for 48 hours. Stained cells were then analyzed on a flow cytometer.

References

ab24933 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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