Anti-IL-20R2 antibody [20RNTC] (ab95824)
Key features and details
- Rat monoclonal [20RNTC] to IL-20R2
- Suitable for: Flow Cyt, ICC/IF
- Reacts with: Mouse, Human
- Isotype: IgG2a
Overview
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Product name
Anti-IL-20R2 antibody [20RNTC]
See all IL-20R2 primary antibodies -
Description
Rat monoclonal [20RNTC] to IL-20R2 -
Host species
Rat -
Specificity
ab95824 recognizes Mouse and Human IL-20R2 in either of its two heterodimeric complexes formed by pairing with IL-20RA or IL-22RA1 -
Tested applications
Suitable for: Flow Cyt, ICC/IFmore details -
Species reactivity
Reacts with: Mouse, Human -
Immunogen
Recombinant fragment corresponding to Mouse IL-20R2 (extracellular).
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Positive control
- Fixed and permeabilized A375 cells
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General notes
Protein previously labeled as IL20RB.
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.20
Preservative: 0.09% Sodium azide
Constituent: 1% PBS -
Concentration information loading...
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Purity
Protein G purified -
Clonality
Monoclonal -
Clone number
20RNTC -
Isotype
IgG2a -
Light chain type
kappa -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
Our Abpromise guarantee covers the use of ab95824 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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Flow Cyt | Use a concentration of 1 - 10 µg/ml. ab18450 - Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody.
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ICC/IF | Use a concentration of 1 - 10 µg/ml. |
Target
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Function
The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL22RA1/IL20RB dimer is a receptor for IL20 and IL24. -
Tissue specificity
Widely expressed with highest levels in skin and testis. Highly expressed in psoriatic skin. -
Sequence similarities
Belongs to the type II cytokine receptor family.
Contains 2 fibronectin type-III domains. -
Cellular localization
Membrane. - Information by UniProt
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Database links
- Entrez Gene: 53833 Human
- Entrez Gene: 213208 Mouse
- Omim: 605621 Human
- SwissProt: Q6UXL0 Human
- Unigene: 61232 Human
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Alternative names
- DIRS1 antibody
- Fibronectin type III domain containing 6 antibody
- FNDC6 antibody
see all
Images
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Immunofluorescent microscopy of fixed and permeabilized A375 cells using 10 µg/ml of ab95824 (right) or Rat IgG2a ? Isotype Control Purified (left) followed by Anti-Rat IgG Biotin and then Streptavidin FITC.
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Mouse IL-20R2-GFP 293 transfectants stained with 0.25ug ab95824 + anti-rat IgG PE
Protocols
Datasheets and documents
References (3)
ab95824 has been referenced in 3 publications.
- Weng YH et al. Blocking IL-19 Signaling Ameliorates Allergen-Induced Airway Inflammation. Front Immunol 10:968 (2019). PubMed: 31114590
- He B et al. A remote cis-acting variant at 3q links glomerular NCK1 to diabetic nephropathy. PLoS One 8:e56414 (2013). WB ; Mouse . PubMed: 23441190
- Hsing CH et al. Upregulated IL-19 in breast cancer promotes tumor progression and affects clinical outcome. Clin Cancer Res 18:713-25 (2012). ICC/IF . PubMed: 22186257