Anti-IL-23 antibody [B-Z23] - BSA and Azide free (ab84471)
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL-23 antibody [B-Z23] (ab84471)](https://www.abcam.com/ps/products/84/ab84471/Images/ab84471-467750-anti-il23-antibody-bz23-immunohistochemistry-skin-human.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL-23 antibody [B-Z23] (ab84471)")
Key features and details
- Mouse monoclonal [B-Z23] to IL-23 - BSA and Azide free
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG1
Overview
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Product name
Anti-IL-23 antibody [B-Z23] - BSA and Azide free
See all IL-23 primary antibodies -
Description
Mouse monoclonal [B-Z23] to IL-23 - BSA and Azide free -
Host species
Mouse -
Specificity
Recognizes both recombinant and natural human IL23, p19 sub-unit. -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human -
Immunogen
Recombinant full length protein corresponding to Human IL-23.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.30
Constituent: 100% PBS
Sterile-filtered through 0.22 µm. Carrier and preservative free -
Carrier free
Yes -
Concentration information loading... -
Purity
Ion Exchange Chromatography -
Purification notes
Sterile-filtered through 0.22 µm and treated to remove endotoxins. -
Clonality
Monoclonal -
Clone number
B-Z23 -
Myeloma
x63-Ag8.653 -
Isotype
IgG1 -
Light chain type
kappa -
Research areas
Associated products
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Alternative Versions
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab84471 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| IHC-P |
1/500.
|
| Notes |
|---|
|
IHC-P
1/500. |
Target
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Function
Associates with IL12B to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. -
Tissue specificity
Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level). -
Sequence similarities
Belongs to the IL-6 superfamily. -
Developmental stage
Expressed by newborns dendritic cells. -
Cellular localization
Secreted. Secreted upon association with IL12B. - Information by UniProt
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Database links
- Entrez Gene: 3593 Human
- Entrez Gene: 51561 Human
- Omim: 161561 Human
- Omim: 605580 Human
- SwissProt: P29460 Human
- SwissProt: Q9NPF7 Human
- Unigene: 382212 Human
- Unigene: 98309 Human
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Alternative names
- IL 23 A antibody
- IL 23 antibody
- IL 23 subunit alpha antibody
see all
Images
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL-23 antibody [B-Z23] (ab84471)
Paraffin embedded human psoriasis lesion tissue labelling IL-23 with ab84471 at 1/500 dilution (Red). DAPI (Blue).
Protocols
Datasheets and documents
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Datasheet download
References (1)
ab84471 has been referenced in 1 publication.
- Zhang L et al. IL-23 selectively promotes the metastasis of colorectal carcinoma cells with impaired Socs3 expression via the STAT5 pathway. Carcinogenesis 35:1330-40 (2014). PubMed: 24464786
