Overview

  • Product name

  • Description

    Rabbit polyclonal to IL-28B
  • Host species

    Rabbit
  • Specificity

    ab181411 may cross react with IL28A and IL29.
  • Tested applications

    Suitable for: WB, ICC/IFmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human IL-28B (internal sequence). Peptide corresponds to 17 amino acids near the center. (NP_742151)
    Database link: Q8IZI9

  • Positive control

    • HeLa cells and cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab181411 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 16 kDa (predicted molecular weight: 22 kDa).
ICC/IF Use a concentration of 5 µg/ml.

Target

  • Function

    Cytokine with immunomodulatory activity. Up-regulates MHC class I antigen expression. Displays potent antiviral activity. Also displays antitumor activity. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway.
  • Sequence similarities

    Belongs to the IL-28/IL-29 family.
  • Cellular localization

    Secreted.
  • Information by UniProt
  • Database links

  • Alternative names

    • Cytokine ZCYTO22 antibody
    • IFN-lambda-3 antibody
    • IFN-lambda-4 antibody
    • IL-28B antibody
    • IL-28C antibody
    • IL28B antibody
    • IL28B_HUMAN antibody
    • IL28C antibody
    • Interferon lambda-3 antibody
    • Interferon lambda-4 antibody
    • interleukin 28B (interferon, lambda 3) antibody
    • Interleukin 28C antibody
    • Interleukin-28B antibody
    • Interleukin-28C antibody
    see all

Images

  • Lane 1 : Anti-IL-28B antibody (ab181411) at 1 µg/ml
    Lane 2 : Anti-IL-28B antibody (ab181411) at 2 µg/ml

    All lanes : HeLa cell lysate

    Lysates/proteins at 15 µg per lane.

    Developed using the ECL technique.

    Predicted band size: 22 kDa
    Observed band size: 16 kDa
    why is the actual band size different from the predicted?

  • Immunofluorescence analysis of HeLa cells, labeling IL28B using ab181411 at 5 μg/mL.

References

ab181411 has not yet been referenced specifically in any publications.

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