Anti-IL-4 antibody (ab126870)
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Overview
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Product nameAnti-IL-4 antibody
See all IL-4 primary antibodies -
DescriptionRabbit polyclonal to IL-4
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Host speciesRabbit
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Tested applicationsSuitable for: WB, IP, ELISA, Neutralisingmore details
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Species reactivityReacts with: Human
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Immunogen
Recombinant full length protein corresponding to Human IL-4 aa 25-153.
Properties
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FormLiquid
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
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Storage bufferPreservative: 0.025% Sodium azide
Constituents: 0.45% Sodium chloride, 0.1% Dibasic monohydrogen sodium phosphate -
Concentration information loading... -
PurityImmunogen affinity purified
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ClonalityPolyclonal
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IsotypeIgG
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Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
Our Abpromise guarantee covers the use of ab126870 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| WB | Use at an assay dependent concentration. Predicted molecular weight: 17 kDa. Use 0.5µg (0.5ng/lane). | |
| IP | Use at an assay dependent concentration. | |
| ELISA | Use at an assay dependent concentration. Use 0.2ng/well. | |
| Neutralising | Use at an assay dependent concentration. |
Target
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FunctionParticipates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.
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Involvement in diseaseGenetic variations in IL4 may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.
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Sequence similaritiesBelongs to the IL-4/IL-13 family.
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Cellular localizationSecreted.
- Information by UniProt
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Database links
- Entrez Gene: 3565 Human
- Omim: 147780 Human
- SwissProt: P05112 Human
- Unigene: 73917 Human
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Alternative names
- B cell growth factor 1 antibody
- B cell IgG differentiation factor antibody
- B Cell Stimulatory Factor 1 antibody
see all
References
ab126870 has not yet been referenced specifically in any publications.
