Overview

  • Product name

    Anti-IL-4 antibody [C1]
    See all IL-4 primary antibodies
  • Description

    Mouse monoclonal [C1] to IL-4
  • Host species

    Mouse
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Human, Pig
    Predicted to work with: Chimpanzee, Cynomolgus monkey, Rhesus monkey
  • Immunogen

    Recombinant full length protein (His-tag) corresponding to Human IL-4 aa 25-153. N-terminal His-tag (Expressed in E.coli).
    Sequence:

    HKCDITLQEIIKTLNSLTEQKTLCTELTVTDIFAASKNTTEKETFCRAAT VLRQFYSHHEKDTRCLGATAQQFHRHKQLIRFLKRLDRNLWGLAGLNSCP VKEANQSTLENFLERLKTIMREKYSKCSS


    Database link: P05112

  • Positive control

    • IHC-P: Human pancreas, prostate gland and breast cancer tissues. WB: Pig spleen lysate; Recombinant human IL4 protein.

Properties

Applications

Our Abpromise guarantee covers the use of ab239508 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 5 - 30 µg/ml.
WB Use a concentration of 0.5 - 5 µg/ml. Predicted molecular weight: 17 kDa.

Target

  • Function

    Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.
  • Involvement in disease

    Genetic variations in IL4 may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.
  • Sequence similarities

    Belongs to the IL-4/IL-13 family.
  • Cellular localization

    Secreted.
  • Information by UniProt
  • Database links

    see all
  • Alternative names

    • B cell growth factor 1 antibody
    • B cell IgG differentiation factor antibody
    • B Cell Stimulatory Factor 1 antibody
    • B-cell stimulatory factor 1 antibody
    • BCGF 1 antibody
    • BCGF1 antibody
    • Binetrakin antibody
    • BSF-1 antibody
    • BSF1 antibody
    • IGG1 induction factor antibody
    • IL 4 antibody
    • IL-4 antibody
    • IL4 antibody
    • IL4_HUMAN antibody
    • Il4e12 antibody
    • Interleukin 4 antibody
    • Interleukin 4 variant 2 antibody
    • Interleukin 4, isoform 1 antibody
    • Interleukin-4 antibody
    • Lymphocyte stimulatory factor 1 antibody
    • MGC79402 antibody
    • Pitrakinra antibody
    see all

Images

  • Paraffin-embedded human pancreas tissue stained for IL4 using ab239508 at 30 µg/ml in immunohistochemical analysis. DAB staining.

  • Anti-IL-4 antibody [C1] (ab239508) at 3 µg/ml + Pig spleen lysate

    Secondary
    HRP-Linked Rabbit Anti-Mouse IgG at 1/5000 dilution

    Predicted band size: 17 kDa

  • Paraffin-embedded human prostate gland tissue stained for IL4 using ab239508 at 30 µg/ml in immunohistochemical analysis. DAB staining.

  • Paraffin-embedded human breast cancer tissue stained for IL4 using ab239508 at 30 µg/ml in immunohistochemical analysis. DAB staining.

  • Anti-IL-4 antibody [C1] (ab239508) at 3 µg/ml + Recombinant human IL4 protein

    Secondary
    HRP-Linked Rabbit Anti-Mouse IgG at 1/5000 dilution

    Predicted band size: 17 kDa

References

ab239508 has not yet been referenced specifically in any publications.

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There are currently no Customer reviews or Questions for ab239508.
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