Overview

  • Product name
    Anti-IL-6R antibody [B-F19]
    See all IL-6R primary antibodies
  • Description
    Mouse monoclonal [B-F19] to IL-6R
  • Host species
    Mouse
  • Specificity
    This antibody is specific for IL6R. (Recognises both soluble and membrane bound IL6R)
  • Tested applications
    Suitable for: Flow Cyt, Inhibition Assaymore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Tissue, cells or virus corresponding to IL-6R.

  • General notes

    Abcam is committed to meeting high standards of ethical manufacturing and has decided to discontinue this product by June 2019 as it has been generated by the ascites method. We are sorry for any inconvenience this may cause. 

     

Properties

Applications

Our Abpromise guarantee covers the use of ab27405 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt
Inhibition Assay
  • Application notes
    Flow Cyt: Use at an assay dependent dilution.

    Blocks IL6 induced proliferation of XG-1 cell line.
    Blocks IL6 binding to its receptor.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis.
      Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity.
    • Tissue specificity
      Isoform 2 is expressed in peripheral blood mononuclear cells and weakly found in urine and serum.
    • Sequence similarities
      Belongs to the type I cytokine receptor family. Type 3 subfamily.
      Contains 1 fibronectin type-III domain.
      Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
    • Domain
      The two fibronectin type-III-like domains, contained in the N-terminal part, form together a cytokine-binding domain.
      The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
    • Post-translational
      modifications
      A short soluble form may also be released from the membrane by proteolysis.
    • Cellular localization
      Secreted and Basolateral cell membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • CD 126 antibody
      • CD126 antibody
      • CD126 antigen antibody
      • gp80 antibody
      • IL 6R 1 antibody
      • IL 6R alpha antibody
      • IL 6R antibody
      • IL-6 receptor alpha chain antibody
      • IL-6 receptor subunit alpha antibody
      • IL-6R 1 antibody
      • IL-6R subunit alpha antibody
      • IL-6R-alpha antibody
      • IL-6RA antibody
      • IL6Q antibody
      • Il6r antibody
      • IL6RA antibody
      • IL6RA_HUMAN antibody
      • IL6RQ antibody
      • Interleukin 6 receptor antibody
      • interleukin 6 receptor, alpha antibody
      • Interleukin-6 receptor subunit alpha antibody
      • Membrane glycoprotein 80 antibody
      • MGC30256 antibody
      see all

    Images

    • Ab27405, staining IL6R by FACS.

    References

    This product has been referenced in:
    • Larregina AT  et al. Pattern of cytokine receptors expressed by human dendritic cells migrated from dermal explants. Immunology 91:303-13 (1997). Read more (PubMed: 9227332) »
    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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