Anti-IL1 Receptor I/IL-1R-1 antibody [REG21] (ab8154)
Key features and details
- Rat monoclonal [REG21] to IL1 Receptor I/IL-1R-1
- Suitable for: Inhibition Assay, IP, Purification, WB
- Reacts with: Mouse
- Isotype: IgG1
Overview
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Product name
Anti-IL1 Receptor I/IL-1R-1 antibody [REG21]
See all IL1 Receptor I/IL-1R-1 primary antibodies -
Description
Rat monoclonal [REG21] to IL1 Receptor I/IL-1R-1 -
Host species
Rat -
Specificity
Binds to soluble mouse interleukin-1 receptor type I. Interleukin-1 signal is transduced through the type I receptor. -
Tested applications
Suitable for: Inhibition Assay, IP, Purification, WBmore details -
Species reactivity
Reacts with: Mouse -
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
Preservative: 0.02% Sodium azide -
Concentration information loading...
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Purity
Protein G purified -
Clonality
Monoclonal -
Clone number
REG21 -
Isotype
IgG1 -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab8154 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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Inhibition Assay |
Use at an assay dependent concentration.
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IP |
Use at an assay dependent concentration.
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Purification |
Use at an assay dependent concentration.
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WB |
Use at an assay dependent concentration.
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Notes |
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Inhibition Assay
Use at an assay dependent concentration. |
IP
Use at an assay dependent concentration. |
Purification
Use at an assay dependent concentration. |
WB
Use at an assay dependent concentration. |
Target
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Function
Receptor for interleukin-1 alpha (IL-1A), beta (IL-1B), and interleukin-1 receptor antagonist protein (IL-1RA). Binding to the agonist leads to the activation of NF-kappa-B. Signaling involves formation of a ternary complex containing IL1RAP, TOLLIP, MYD88, and IRAK1 or IRAK2. -
Sequence similarities
Belongs to the interleukin-1 receptor family.
Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 TIR domain. -
Cellular localization
Membrane. - Information by UniProt
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Database links
- Entrez Gene: 16177 Mouse
- SwissProt: P13504 Mouse
- Unigene: 896 Mouse
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Alternative names
- Antigen CD121a antibody
- CD121 antigen-like family member A antibody
- CD121a antibody
see all
Protocols
Datasheets and documents
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Datasheet download
References (1)
ab8154 has been referenced in 1 publication.
- Pasi S et al. Toll/Interleukin-1 Receptor Domain Derived from TcpC (TIR-TcpC) Ameliorates Experimental Autoimmune Arthritis by Down-modulating Th17 Cell Response. J Biol Chem 291:12358-69 (2016). PubMed: 27022030