Product nameAnti-IL1 Receptor I/IL-1R-1 antibody
See all IL1 Receptor I/IL-1R-1 primary antibodies
DescriptionRabbit polyclonal to IL1 Receptor I/IL-1R-1
Tested applicationsSuitable for: ICC/IF, WB, IHC-Pmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat
Recombinant fragment corresponding to Human IL1 Receptor I/IL-1R-1 aa 18-241.
- Human fetal spleen lysate. HeLa cell lysate. Human fetal skin tissue.
Previously labelled as IL1 Receptor I.
FormLyophilised:Reconstitute with 200ul distilled sterile water. Please note that if you receive this product in liquid form it has already been reconstituted as described and no further reconstitution is necessary.
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
Storage bufferPreservative: 0.02% Sodium azide
Constituent: 1% BSA
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab106278 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|ICC/IF||Use at an assay dependent concentration. PubMed: 24950657|
|WB||1/500 - 1/1000. Detects a band of approximately 75 kDa (predicted molecular weight: 65 kDa).|
|IHC-P||1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.|
FunctionReceptor for interleukin-1 alpha (IL-1A), beta (IL-1B), and interleukin-1 receptor antagonist protein (IL-1RA). Binding to the agonist leads to the activation of NF-kappa-B. Signaling involves formation of a ternary complex containing IL1RAP, TOLLIP, MYD88, and IRAK1 or IRAK2.
Sequence similaritiesBelongs to the interleukin-1 receptor family.
Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 TIR domain.
- Information by UniProt
- Antigen CD121a antibody
- CD121 antigen-like family member A antibody
- CD121a antibody
ab106278 staining IL-1 Receptor 1 / IL-1R-1 antibody in foetal epithelial skin tissue by immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections). Antibody dilution 1/100.
All lanes : Anti-IL1 Receptor I/IL-1R-1 antibody (ab106278) at 1/500 dilution
Lane 1 : Human fetal spleen lysate
Lane 2 : HeLa cell lysate
Predicted band size: 65 kDa
This product has been referenced in:
- Paish HL et al. Fibroblasts Promote Inflammation and Pain via IL-1a Induction of the Monocyte Chemoattractant Chemokine (C-C Motif) Ligand 2. Am J Pathol 188:696-714 (2018). IHC ; Human . Read more (PubMed: 29248462) »
- Lu Q et al. Comprehensive microRNA profiling reveals potential augmentation of the IL1 pathway in rheumatic heart valve disease. BMC Cardiovasc Disord 18:53 (2018). Read more (PubMed: 29548280) »