Anti-IL1 Receptor I/IL-1R-1 antibody [D1f3] (ab8156)
- Datasheet
- References
- Protocols
Overview
-
Product name
Anti-IL1 Receptor I/IL-1R-1 antibody [D1f3]
See all IL1 Receptor I/IL-1R-1 primary antibodies -
Description
Rat monoclonal [D1f3] to IL1 Receptor I/IL-1R-1 -
Host species
Rat -
Specificity
Binds to soluble mouse interleukin-1 receptor type I. -
Tested applications
Suitable for: Inhibition Assay, WBmore details -
Species reactivity
Reacts with: Mouse -
General notes
The IL-1 system includes two agonists (IL-1 alpha and IL-1 alpha), converting enzymes, antagonists, two receptors (IL-1 RI and IL-1 RII) and the IL-1 receptor accessory protein. Interleukin-1 signal is transduced through the type I receptor.
Western blots, as well as inhibition in biological assays, in vitro as well as in vivo (although for in vitro use the monoclonal antibody ab8154 is receommended).
Previously labelled as IL1 Receptor I.
Properties
-
Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
Preservative: 0.02% Sodium azide -
Concentration information loading... -
Purity
Protein G purified -
Primary antibody notes
The IL-1 system includes two agonists (IL-1 alpha and IL-1 alpha), converting enzymes, antagonists, two receptors (IL-1 RI and IL-1 RII) and the IL-1 receptor accessory protein. Interleukin-1 signal is transduced through the type I receptor. -
Clonality
Monoclonal -
Clone number
D1f3 -
Isotype
IgG1 -
Research areas
Associated products
-
Compatible Secondaries
-
Isotype control
-
Recombinant Protein
Applications
Our Abpromise guarantee covers the use of ab8156 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| Inhibition Assay | Use at an assay dependent concentration. | |
| WB | Use at an assay dependent concentration. |
Target
-
Function
Receptor for interleukin-1 alpha (IL-1A), beta (IL-1B), and interleukin-1 receptor antagonist protein (IL-1RA). Binding to the agonist leads to the activation of NF-kappa-B. Signaling involves formation of a ternary complex containing IL1RAP, TOLLIP, MYD88, and IRAK1 or IRAK2. -
Sequence similarities
Belongs to the interleukin-1 receptor family.
Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 TIR domain. -
Cellular localization
Membrane. - Information by UniProt
-
Database links
- Entrez Gene: 16177 Mouse
- SwissProt: P13504 Mouse
- Unigene: 896 Mouse
-
Alternative names
- Antigen CD121a antibody
- CD121 antigen-like family member A antibody
- CD121a antibody
see all
Protocols
Datasheets and documents
References
ab8156 has not yet been referenced specifically in any publications.
