Key features and details
- Rat monoclonal [REG21] to IL1 Receptor I/IL-1R-1
- Suitable for: IP, Inhibition Assay, WB, Purification
- Reacts with: Mouse
- Isotype: IgG1
Product nameAnti-IL1 Receptor I/IL-1R-1 antibody [REG21]
See all IL1 Receptor I/IL-1R-1 primary antibodies
DescriptionRat monoclonal [REG21] to IL1 Receptor I/IL-1R-1
SpecificityBinds to soluble mouse interleukin-1 receptor type I. Interleukin-1 signal is transduced through the type I receptor.
Tested applicationsSuitable for: IP, Inhibition Assay, WB, Purificationmore details
Species reactivityReacts with: Mouse
Previously labelled as IL1 Receptor I.
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferPreservative: 0.02% Sodium azide
Concentration information loading...
PurityProtein G purified
Our Abpromise guarantee covers the use of ab8154 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Inhib: Use at an assay dependent dilution.
P: Use at an assay dependent dilution.
WB: Use at an assay dependent dilution.
ab8154 can be used for inhibition in biological assays (in vitro and in vivo).
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionReceptor for interleukin-1 alpha (IL-1A), beta (IL-1B), and interleukin-1 receptor antagonist protein (IL-1RA). Binding to the agonist leads to the activation of NF-kappa-B. Signaling involves formation of a ternary complex containing IL1RAP, TOLLIP, MYD88, and IRAK1 or IRAK2.
Sequence similaritiesBelongs to the interleukin-1 receptor family.
Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 TIR domain.
- Information by UniProt
- Antigen CD121a antibody
- CD121 antigen-like family member A antibody
- CD121a antibody
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab8154 has been referenced in 1 publication.
- Pasi S et al. Toll/Interleukin-1 Receptor Domain Derived from TcpC (TIR-TcpC) Ameliorates Experimental Autoimmune Arthritis by Down-modulating Th17 Cell Response. J Biol Chem 291:12358-69 (2016). PubMed: 27022030