Anti-IL-13 receptor alpha 1 antibody (ab79277)
Key features and details
- Rabbit polyclonal to IL-13 receptor alpha 1
- Suitable for: WB, IHC-P, ICC/IF
- Reacts with: Mouse, Human
- Isotype: IgG
Overview
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Product name
Anti-IL-13 receptor alpha 1 antibody
See all IL-13 receptor alpha 1 primary antibodies -
Description
Rabbit polyclonal to IL-13 receptor alpha 1 -
Host species
Rabbit -
Tested applications
Suitable for: WB, IHC-P, ICC/IFmore details -
Species reactivity
Reacts with: Mouse, Human -
Immunogen
Synthetic peptide corresponding to Human IL-13 receptor alpha 1 (phospho Y405). (D-I-Y-E-K)
Database link: P78552 -
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
Storage buffer
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.5% BSA
Without Mg2+ and Ca2+ -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Conjugation kits
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab79277 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
WB | (1) |
1/500 - 1/1000. Predicted molecular weight: 47 kDa.
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IHC-P |
1/50 - 1/100.
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ICC/IF | (1) |
1/500 - 1/1000.
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Notes |
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WB
1/500 - 1/1000. Predicted molecular weight: 47 kDa. |
IHC-P
1/50 - 1/100. |
ICC/IF
1/500 - 1/1000. |
Target
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Function
Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity. -
Tissue specificity
Ubiquitous. Highest levels in heart, liver, skeletal muscle and ovary; lowest levels in brain, lung and kidney. Also found in B-cells, T-cells and endothelial cells. -
Sequence similarities
Belongs to the type I cytokine receptor family. Type 5 subfamily. -
Domain
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation. -
Cellular localization
Membrane. - Information by UniProt
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Database links
- Entrez Gene: 3597 Human
- Entrez Gene: 16164 Mouse
- Omim: 300119 Human
- SwissProt: P78552 Human
- SwissProt: O09030 Mouse
- Unigene: 496646 Human
- Unigene: 24208 Mouse
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Alternative names
- bB128O4.2.1 (interleukin 13 receptor, alpha 1) antibody
- Cancer/testis antigen 19 antibody
- CD213a1 antibody
see all
Images
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All lanes : Anti-IL-13 receptor alpha 1 antibody (ab79277) at 1/500 dilution
Lane 1 : COLO cell extracts
Lane 2 : HT29 cell extracts
Lane 3 : A549 cell extracts
Lane 4 : 293 cell extracts
Lane 5 : COLO cell extracts with immunising peptide at 10 µg
Lysates/proteins at 30 µg per lane.
Predicted band size: 47 kDa
Observed band size: 50 kDa why is the actual band size different from the predicted? -
ab79277 at 1/50 dilution staining IL-13 receptor alpha 1 in human breast carcinoma by Immunohistochemistry using paraffin-embedded tissue, in the absence or presence of the immunising peptide.
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ab79277 at 1/500 dilution staining IL-13 receptor alpha 1 in NIH3T3 cells by Immunofluorescence, in the absence or presence of the immunising peptide.
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (17)
ab79277 has been referenced in 17 publications.
- Shi J et al. Loss of Interleukin-13-Receptor-Alpha-1 Induces Apoptosis and Promotes EMT in Pancreatic Cancer. Int J Mol Sci 23:N/A (2022). PubMed: 35409019
- Lu Z et al. IL-20 promotes cutaneous inflammation and peripheral itch sensation in atopic dermatitis. FASEB J 36:e22334 (2022). PubMed: 35486004
- Van Broeckhoven J et al. Macrophage-based delivery of interleukin-13 improves functional and histopathological outcomes following spinal cord injury. J Neuroinflammation 19:102 (2022). PubMed: 35488301
- Zhu M et al. Interleukin-13 promotes cellular senescence through inducing mitochondrial dysfunction in IgG4-related sialadenitis. Int J Oral Sci 14:29 (2022). PubMed: 35718799
- Mehrara BJ et al. Pilot Study of Anti-Th2 Immunotherapy for the Treatment of Breast Cancer-Related Upper Extremity Lymphedema. Biology (Basel) 10:N/A (2021). PubMed: 34571811