Anti-IL-17RC antibody (ab69673)
Key features and details
- Mouse polyclonal to IL-17RC
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-IL-17RC antibody
See all IL-17RC primary antibodies -
Description
Mouse polyclonal to IL-17RC -
Host species
Mouse -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human -
Immunogen
Recombinant full length protein within Human IL-17RC aa 1-550. The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements.
Database link: AAH06411.1 -
Positive control
- IL17RC transfected 293T cell lysate.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
pH: 7.40
Constituent: 100% PBS -
Concentration information loading...
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Purity
Protein G purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab69673 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
Notes |
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WB: 1/500 - 1/1000. Predicted molecular weight: 86 kDa (SwissProt isoform 1).
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
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Relevance
IL-17RC is a single pass transmembrane protein that shares limited similarity with the interleukin 17 receptor. It is widely expressed in non leukocyte tissues and forms a heteromeric receptor for IL-17 with IL-17RA. At least four different isoforms are known to exist. -
Cellular localization
Cell membrane; Single pass type I membrane protein. Note: soluble isoforms may be produced. -
Database links
- Entrez Gene: 84818 Human
- Omim: 610925 Human
- SwissProt: Human
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Alternative names
- IL 17 receptor C antibody
- IL 17RC antibody
- IL 17RL antibody
see all
Images
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All lanes : Anti-IL-17RC antibody (ab69673) at 1/500 dilution
Lane 1 : IL17RC transfected 293T cell lysate
Lane 2 : Non transfected 293T cell lysate
Lysates/proteins at 25 µg per lane.
Secondary
All lanes : Goat Anti-Mouse IgG (H&L)-HRP conjugated at 1/2500 dilution
Predicted band size: 86 kDa
Observed band size: 70 kDa why is the actual band size different from the predicted?
Datasheets and documents
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Datasheet download
References (6)
ab69673 has been referenced in 6 publications.
- Janiczek M et al. Expression Levels of IL-17A, IL-17F, IL-17RA, and IL-17RC in Prostate Cancer with Taking into Account the Histological Grade according to Gleason Scale in Comparison to Benign Prostatic Hyperplasia: In Search of New Therapeutic Options. J Immunol Res 2020:4910595 (2020). PubMed: 32537467
- Crawford MP et al. CD4 T cell-intrinsic role for the T helper 17 signature cytokine IL-17: Effector resistance to immune suppression. Proc Natl Acad Sci U S A 117:19408-19414 (2020). PubMed: 32719138
- Wang P et al. Potential role of the IL17RC gene in the thoracic ossification of the posterior longitudinal ligament. Int J Mol Med 43:2005-2014 (2019). PubMed: 30864693
- Wang P et al. IL17RC affects the predisposition to thoracic ossification of the posterior longitudinal ligament. J Orthop Surg Res 14:210 (2019). PubMed: 31291973
- Roussel L et al. IL-17 promotes p38 MAPK-dependent endothelial activation enhancing neutrophil recruitment to sites of inflammation. J Immunol 184:4531-7 (2010). IHC-P ; Human . PubMed: 20228195
- Roussel L & Rousseau S IL-17 primes airway epithelial cells lacking functional Cystic Fibrosis Transmembrane conductance Regulator (CFTR) to increase NOD1 responses. Biochem Biophys Res Commun 391:505-9 (2010). IHC-P ; Human . PubMed: 19931506