Anti-IL-1RAPL1 antibody [MM0353-3R16] (ab90453)
Key features and details
- Mouse monoclonal [MM0353-3R16] to IL-1RAPL1
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG2
Overview
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Product name
Anti-IL-1RAPL1 antibody [MM0353-3R16]
See all IL-1RAPL1 primary antibodies -
Description
Mouse monoclonal [MM0353-3R16] to IL-1RAPL1 -
Host species
Mouse -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human -
Immunogen
Recombinant fragment corresponding to Human IL-1RAPL1.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
Constituent: PBS -
Concentration information loading...
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Purity
Protein G purified -
Purification notes
The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and filtered through a 0.2 µm filter. -
Clonality
Monoclonal -
Clone number
MM0353-3R16 -
Isotype
IgG2 -
Research areas
Associated products
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Compatible Secondaries
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab90453 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/500 - 1/2000. Predicted molecular weight: 80 kDa.
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Notes |
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WB
1/500 - 1/2000. Predicted molecular weight: 80 kDa. |
Target
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Function
May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. -
Tissue specificity
Detected at low levels in heart, skeletal muscle, ovary, skin, amygdala, caudate nucleus, corpus callosum, hippocampus, substantia nigra and thalamus. Detected at very low levels in tonsil, prostate, testis, small intestine, placenta, colon and fetal liver. -
Involvement in disease
Defects in IL1RAPL1 are the cause of mental retardation X-linked type 21 (MRX21) [MIM:300143]. Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs. -
Sequence similarities
Belongs to the interleukin-1 receptor family.
Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 TIR domain. -
Cellular localization
Cell membrane. Cytoplasm. May localize to the cell body and growth cones of dendrite-like processes. - Information by UniProt
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Database links
- Entrez Gene: 11141 Human
- Omim: 300206 Human
- SwissProt: Q9NZN1 Human
- Unigene: 658912 Human
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Alternative names
- IL 1 RAPL 1 antibody
- IL 1RAPL 1 antibody
- IL-1-RAPL-1 antibody
see all
Images
Datasheets and documents
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Datasheet download
References (0)
ab90453 has not yet been referenced specifically in any publications.