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  1. Link

    il2-receptor-betap75-antibody-1g11c6-ab233792.pdf

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Immunology Innate Immunity Cytokines Interleukins
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Anti-IL2 Receptor beta/p75 antibody [1G11C6] (ab233792)

  • Datasheet
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Western blot - Anti-IL2 Receptor beta/p75 antibody [1G11C6] (ab233792)
  • Western blot - Anti-IL2 Receptor beta/p75 antibody [1G11C6] (ab233792)
  • Flow Cytometry - Anti-IL2 Receptor beta/p75 antibody [1G11C6] (ab233792)
  • Flow Cytometry - Anti-IL2 Receptor beta/p75 antibody [1G11C6] (ab233792)

Key features and details

  • Mouse monoclonal [1G11C6] to IL2 Receptor beta/p75
  • Suitable for: WB, Flow Cyt
  • Reacts with: Human
  • Isotype: IgG2b

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Overview

  • Product name

    Anti-IL2 Receptor beta/p75 antibody [1G11C6]
    See all IL2 Receptor beta/p75 primary antibodies
  • Description

    Mouse monoclonal [1G11C6] to IL2 Receptor beta/p75
  • Host species

    Mouse
  • Tested applications

    Suitable for: WB, Flow Cytmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Chimpanzee, Cynomolgus monkey
  • Immunogen

    Recombinant fragment corresponding to Human IL2 Receptor beta/p75 aa 1-250. Expressed in E.coli.
    Database link: P14784

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
  • Positive control

    • WB: Recombinant human IL2 Receptor beta/p75 (aa 27-240) protein; IL2 Receptor beta/p75 (aa 27-240)-hIgG-Fc-transfected HEK-293 cell lysate. Flow cyt: HL-60 and Jurkat cells.
  • General notes

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    Preservative: 0.05% Sodium azide
    Constituent: PBS
  • Concentration information loading...
  • Purity

    Protein G purified
  • Purification notes

    Purified from tissue culture supernatant.
  • Clonality

    Monoclonal
  • Clone number

    1G11C6
  • Isotype

    IgG2b
  • Research areas

    • Immunology
    • Innate Immunity
    • Cytokines
    • Interleukins
    • Signal Transduction
    • Protein Phosphorylation
    • Tyrosine Kinases
    • Receptor Tyrosine Kinases
    • Stem Cells
    • Hematopoietic Progenitors
    • Lymphoid
    • B Lymphocytic Lineage
    • Stem Cells
    • Hematopoietic Progenitors
    • Myeloid
    • Monocytic Lineage
    • Immunology
    • Adaptive Immunity
    • Regulatory T Cells

Associated products

  • Compatible Secondaries

    • Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (ab150113)
    • Goat Anti-Mouse IgG H&L (HRP) (ab205719)
  • Isotype control

    • Mouse IgG2b, kappa monoclonal [7E10G10] - Isotype Control (ab170192)
  • Recombinant Protein

    • Recombinant human IL2 Receptor beta/p75 protein (Fc Chimera) (ab84068)

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab233792 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
1/500 - 1/2000.
Flow Cyt
1/200 - 1/400.
Notes
WB
1/500 - 1/2000.
Flow Cyt
1/200 - 1/400.

Target

  • Function

    Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2.
  • Sequence similarities

    Belongs to the type I cytokine receptor family. Type 4 subfamily.
    Contains 1 fibronectin type-III domain.
  • Domain

    The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
    The box 1 motif is required for JAK interaction and/or activation.
  • Cellular localization

    Membrane.
  • Target information above from: UniProt accession P14784 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 3560 Human
    • Omim: 146710 Human
    • SwissProt: Q38J84 Chimpanzee
    • SwissProt: Q38J85 Cynomolgus monkey
    • SwissProt: P14784 Human
    • Unigene: 474787 Human
    • Alternative names

      • CD122 antibody
      • CD122 antigen antibody
      • High affinity IL 2 receptor beta subunit antibody
      • High affinity IL 2 receptor subunit beta antibody
      • High affinity IL-2 receptor subunit beta antibody
      • IL-2 receptor subunit beta antibody
      • IL-2R subunit beta antibody
      • IL-2RB antibody
      • IL15RB antibody
      • IL2 receptor antibody
      • IL2RB antibody
      • IL2RB_HUMAN antibody
      • Interleukin 2 receptor beta antibody
      • Interleukin-2 receptor subunit beta antibody
      • P70 75 antibody
      • P70-75 antibody
      • P7075 antibody
      • p75 antibody
      see all

    Images

    • Western blot - Anti-IL2 Receptor beta/p75 antibody [1G11C6] (ab233792)
      Western blot - Anti-IL2 Receptor beta/p75 antibody [1G11C6] (ab233792)
      Anti-IL2 Receptor beta/p75 antibody [1G11C6] (ab233792) at 1/500 dilution + Recombinant human IL2 Receptor beta/p75 (aa 27-240) protein


      Expected MW is 51kDa.

    • Western blot - Anti-IL2 Receptor beta/p75 antibody [1G11C6] (ab233792)
      Western blot - Anti-IL2 Receptor beta/p75 antibody [1G11C6] (ab233792)
      All lanes : Anti-IL2 Receptor beta/p75 antibody [1G11C6] (ab233792) at 1/500 dilution

      Lane 1 : Untransfected HEK-293 (human epithelial cell line from embryonic kidney) cell lysate
      Lane 2 : IL2 Receptor beta/p75 (aa 27-240)-hIgG-Fc-transfected HEK-293 cell lysate
    • Flow Cytometry - Anti-IL2 Receptor beta/p75 antibody [1G11C6] (ab233792)
      Flow Cytometry - Anti-IL2 Receptor beta/p75 antibody [1G11C6] (ab233792)

      Flow cytometric analysis of HL-60 (human promyelocytic leukemia cell line) cells labeling IL2 Receptor beta/p75 with ab233792 at 1/200 dilution (green) compared with a negative control (red).

    • Flow Cytometry - Anti-IL2 Receptor beta/p75 antibody [1G11C6] (ab233792)
      Flow Cytometry - Anti-IL2 Receptor beta/p75 antibody [1G11C6] (ab233792)

      Flow cytometric analysis of Jurkat (human T cell leukemia cell line from peripheral blood) cells labeling IL2 Receptor beta/p75 with ab233792 at 1/200 dilution (green) compared with a negative control (red).

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet download

      Download

    References (0)

    Publishing research using ab233792? Please let us know so that we can cite the reference in this datasheet.

    ab233792 has not yet been referenced specifically in any publications.

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