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    il2-receptor-betap75-antibody-epr22892-2-ab263906.pdf

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Immunology Innate Immunity Cytokines Interleukins
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RecombinantRabMAb

Recombinant Anti-IL2 Receptor beta/p75 antibody [EPR22892-2] (ab263906)

  • Datasheet
  • SDS
  • Certificate of Compliance
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Immunocytochemistry/ Immunofluorescence - Anti-IL2 Receptor beta/p75 antibody [EPR22892-2] (ab263906)
  • Flow Cytometry - Anti-IL2 Receptor beta/p75 antibody [EPR22892-2] (ab263906)
  • Anti-IL2 Receptor beta/p75 antibody [EPR22892-2] (ab263906)

Key features and details

  • Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
  • Rabbit monoclonal [EPR22892-2] to IL2 Receptor beta/p75
  • Suitable for: Flow Cyt, ICC/IF
  • Reacts with: Human

Conjugates logo Related conjugates and formulations

Alexa Fluor® 488 Alexa Fluor® 647 Carrier Free PE

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Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
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PE Anti-IL2 Receptor beta/p75 antibody [EPR22892-2] (ab267556)
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Alexa Fluor® 647 Anti-CD28 antibody [EPR23280-63] (ab279696)

View more associated products

Overview

  • Product name

    Anti-IL2 Receptor beta/p75 antibody [EPR22892-2]
    See all IL2 Receptor beta/p75 primary antibodies
  • Description

    Rabbit monoclonal [EPR22892-2] to IL2 Receptor beta/p75
  • Host species

    Rabbit
  • Tested applications

    Suitable for: Flow Cyt, ICC/IFmore details
    Unsuitable for: IHC-P or WB
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment. This information is proprietary to Abcam and/or its suppliers.

  • Positive control

    • ICC/IF: Human PBMC's;Flow Cyt: Human PBMC's.
  • General notes

    This product is a recombinant monoclonal antibody, which offers several advantages including:

    • - High batch-to-batch consistency and reproducibility
    • - Improved sensitivity and specificity
    • - Long-term security of supply
    • - Animal-free production
    For more information see here.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.2
    Preservative: 0.01% Sodium azide
    Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
  • Concentration information loading...
  • Purity

    Protein A purified
  • Clonality

    Monoclonal
  • Clone number

    EPR22892-2
  • Isotype

    IgG
  • Research areas

    • Immunology
    • Innate Immunity
    • Cytokines
    • Interleukins
    • Signal Transduction
    • Protein Phosphorylation
    • Tyrosine Kinases
    • Receptor Tyrosine Kinases
    • Stem Cells
    • Hematopoietic Progenitors
    • Lymphoid
    • B Lymphocytic Lineage
    • Stem Cells
    • Hematopoietic Progenitors
    • Myeloid
    • Monocytic Lineage
    • Immunology
    • Adaptive Immunity
    • Regulatory T Cells

Associated products

  • Alternative Versions

    • Anti-IL2 Receptor beta/p75 antibody [EPR22892-2] - BSA and Azide free (ab264075)
    • Alexa Fluor® 488 Anti-IL2 Receptor beta/p75 antibody [EPR22892-2] (ab267554)
    • Alexa Fluor® 647 Anti-IL2 Receptor beta/p75 antibody [EPR22892-2] (ab267555)
    • PE Anti-IL2 Receptor beta/p75 antibody [EPR22892-2] (ab267556)
  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Isotype control

    • Rabbit IgG, monoclonal [EPR25A] - Isotype Control (ab172730)
  • Related Products

    • Alexa Fluor® 594 Anti-alpha Tubulin antibody [DM1A] - Microtubule Marker (ab195889)

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab263906 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt
1/500.
ICC/IF
1/50.

 

 

Notes
Flow Cyt
1/500.
ICC/IF
1/50.

 

 

Application notes
Is unsuitable for IHC-P or WB.

Target

  • Function

    Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2.
  • Sequence similarities

    Belongs to the type I cytokine receptor family. Type 4 subfamily.
    Contains 1 fibronectin type-III domain.
  • Domain

    The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
    The box 1 motif is required for JAK interaction and/or activation.
  • Cellular localization

    Membrane.
  • Target information above from: UniProt accession P14784 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 3560 Human
    • Omim: 146710 Human
    • SwissProt: P14784 Human
    • Unigene: 474787 Human
    • Alternative names

      • CD122 antibody
      • CD122 antigen antibody
      • High affinity IL 2 receptor beta subunit antibody
      • High affinity IL 2 receptor subunit beta antibody
      • High affinity IL-2 receptor subunit beta antibody
      • IL-2 receptor subunit beta antibody
      • IL-2R subunit beta antibody
      • IL-2RB antibody
      • IL15RB antibody
      • IL2 receptor antibody
      • IL2RB antibody
      • IL2RB_HUMAN antibody
      • Interleukin 2 receptor beta antibody
      • Interleukin-2 receptor subunit beta antibody
      • P70 75 antibody
      • P70-75 antibody
      • P7075 antibody
      • p75 antibody
      see all

    Images

    • Immunocytochemistry/ Immunofluorescence - Anti-IL2 Receptor beta/p75 antibody [EPR22892-2] (ab263906)
      Immunocytochemistry/ Immunofluorescence - Anti-IL2 Receptor beta/p75 antibody [EPR22892-2] (ab263906)

      Immunofluorescent analysis of 4% Paraformaldehyde-fixed, 0.1% Triton X-100 permeabilized PBMC cells labelling IL2 Receptor beta/p75 with ab263906 at 1/50 dilution, followed by ab150077 AlexaFluor®488 Goat anti-Rabbit secondary antibody at 1/1000 dilution (Green). Confocal image showing membranous staining in a subset of Human PBMC cells. is observed. ab195889 Anti-alpha Tubulin antibody [DM1A] - Microtubule Marker (Alexa Fluor® 594) was used to counterstain tubulin at 1/200 dilution (Red). The Nuclear counterstain was DAPI (Blue).

      Secondary antibody only control: Secondary antibody is ab150077 AlexaFluor®488 Goat anti-Rabbit secondary at 1/1000 dilution.

    • Flow Cytometry - Anti-IL2 Receptor beta/p75 antibody [EPR22892-2] (ab263906)
      Flow Cytometry - Anti-IL2 Receptor beta/p75 antibody [EPR22892-2] (ab263906)

      Flow cytometric analysis of Human peripheral blood mononuclear cell (PBMC) cells labelling IL2 Receptor beta/p75 with ab263906 at 1/500 compared with a Rabbit monoclonal IgG (ab172730) isotype control (left) and an unlabelled control (cells without incubation with primary antibody and secondary antibody) (Blue). Goat anti rabbit IgG (Alexa Fluor® 488, ab150077) at 1/2000 dilution was used as the secondary antibody.

      Cells were stained with rabbit IgG (Left) or ab263906 (Right). Then stained with anti-CD56 conjugated to BV421. IL2 Receptor beta/CD122 is constitutively expressed primarily by NK cells (PMID: 24055329). Gated on viable cells.

    • Anti-IL2 Receptor beta/p75 antibody [EPR22892-2] (ab263906)
      Anti-IL2 Receptor beta/p75 antibody [EPR22892-2] (ab263906)

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download

    Certificate of Compliance

    To download a Certificate of Compliance, please enter your Lot number below:

    References (0)

    Publishing research using ab263906? Please let us know so that we can cite the reference in this datasheet.

    ab263906 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

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