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  1. Link

    il3racd123-antibody-il3ra1531-ab268075.pdf

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Immunology Innate Immunity Cytokines Interleukins
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Anti-IL3RA/CD123 antibody [IL3RA/1531] (ab268075)

  • Datasheet
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL3RA/CD123 antibody [IL3RA/1531] (ab268075)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL3RA/CD123 antibody [IL3RA/1531] (ab268075)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL3RA/CD123 antibody [IL3RA/1531] (ab268075)
  • Protein Array - Anti-IL3RA/CD123 antibody [IL3RA/1531] (ab268075)

Key features and details

  • Mouse monoclonal [IL3RA/1531] to IL3RA/CD123
  • Suitable for: IHC-P, Protein Array
  • Reacts with: Human
  • Isotype: IgG2b

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Anti-MERTK antibody [Y323] (ab52968)

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Overview

  • Product name

    Anti-IL3RA/CD123 antibody [IL3RA/1531]
    See all IL3RA/CD123 primary antibodies
  • Description

    Mouse monoclonal [IL3RA/1531] to IL3RA/CD123
  • Host species

    Mouse
  • Tested applications

    Suitable for: IHC-P, Protein Arraymore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment within Human IL3RA/CD123 aa 26-171. The exact sequence is proprietary.
    Database link: P26951

  • Positive control

    • IHC-P: Human tonsil, lymph node and gastric carcinoma tissues.
  • General notes

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.2
    Preservative: 0.05% Sodium azide
    Constituents: PBS, 0.05% BSA
  • Concentration information loading...
  • Purity

    Protein A/G purified
  • Purification notes

    Purified from Bioreactor concentrate
  • Clonality

    Monoclonal
  • Clone number

    IL3RA/1531
  • Isotype

    IgG2b
  • Light chain type

    kappa
  • Research areas

    • Immunology
    • Innate Immunity
    • Cytokines
    • Interleukins
    • Signal Transduction
    • Adapters
    • Transmembrane

Associated products

  • Alternative Versions

    • Anti-IL3RA/CD123 antibody [IL3RA/1531] - BSA and Azide free (ab268196)
  • Compatible Secondaries

    • Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (ab150113)
    • Goat Anti-Mouse IgG H&L (HRP) (ab205719)

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab268075 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
Use a concentration of 1 - 2 µg/ml. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
Protein Array
Use at an assay dependent concentration.
Notes
IHC-P
Use a concentration of 1 - 2 µg/ml. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
Protein Array
Use at an assay dependent concentration.

Target

  • Function

    This is a receptor for interleukin-3.
  • Sequence similarities

    Belongs to the type I cytokine receptor family. Type 5 subfamily.
  • Domain

    The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
    The box 1 motif is required for JAK interaction and/or activation.
  • Cellular localization

    Membrane.
  • Target information above from: UniProt accession P26951 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 3563 Human
    • Omim: 308385 Human
    • Omim: 430000 Human
    • SwissProt: P26951 Human
    • Unigene: 632790 Human
    • Alternative names

      • CD123 antibody
      • CD123 antigen antibody
      • hIL 3Ra antibody
      • hIL-3Ra antibody
      • hIL3Ra antibody
      • IL 3 receptor alpha SP2 isoform antibody
      • IL 3R alpha antibody
      • IL-3 receptor subunit alpha antibody
      • IL-3R subunit alpha antibody
      • IL-3R-alpha antibody
      • IL-3RA antibody
      • IL3 Receptor alpha antibody
      • IL3R antibody
      • Il3ra antibody
      • IL3RA_HUMAN antibody
      • IL3RAX antibody
      • IL3RAY antibody
      • IL3RX antibody
      • IL3RY antibody
      • Interleukin 3 receptor alpha chain antibody
      • Interleukin 3 receptor, alpha (low affinity) antibody
      • Interleukin 3 receptor, alpha antibody
      • Interleukin-3 Receptor alpha antibody
      • Interleukin-3 receptor subunit alpha antibody
      • Interleukin3 receptor antibody
      • Interleukin3 receptor, Y-chromosomal antibody
      see all

    Images

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL3RA/CD123 antibody [IL3RA/1531] (ab268075)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL3RA/CD123 antibody [IL3RA/1531] (ab268075)

      Formalin-fixed, paraffin-embedded human gastric carcinoma tissue stained for IL3RA/CD123 using ab268075 at 2 μg/ml in immunohistochemical analysis. 

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL3RA/CD123 antibody [IL3RA/1531] (ab268075)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL3RA/CD123 antibody [IL3RA/1531] (ab268075)

      Formalin-fixed, paraffin-embedded human lymph node tissue stained for IL3RA/CD123 using ab268075 at 2 μg/ml in immunohistochemical analysis. 

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL3RA/CD123 antibody [IL3RA/1531] (ab268075)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL3RA/CD123 antibody [IL3RA/1531] (ab268075)

      Formalin-fixed, paraffin-embedded human tonsil tissue stained for IL3RA/CD123 using ab268075 at 2 μg/ml in immunohistochemical analysis. 

    • Protein Array - Anti-IL3RA/CD123 antibody [IL3RA/1531] (ab268075)
      Protein Array - Anti-IL3RA/CD123 antibody [IL3RA/1531] (ab268075)

      Protein Array containing >19,000 full-length human proteins using ab268075. Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet download

      Download

    References (0)

    Publishing research using ab268075? Please let us know so that we can cite the reference in this datasheet.

    ab268075 has not yet been referenced specifically in any publications.

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    There are currently no Customer reviews or Questions for ab268075.
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