Overview

  • Product name

    Ilimaquinone, Cytoplasmic microtubule inhibitor
  • Description

    Cytoplasmic microtubule inhibitor. Disrupts Golgi membranes.
  • Biological description

    Induces depolymerisation of cytoplasmic microtubules. Induces a reversible vesiculation of Golgi membranes blocking downstream protein transport. Inhibitor of gap junction communications. Cell-permeable. Anti-inflammatory and anticancer activity.
  • Purity

    > 98%
  • CAS Number

    71678-03-0
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Motti CA  et al. Comparison of the biological properties of several marine sponge-derived sesquiterpenoid quinones. Molecules 12:1376-88 (2007). Read more (PubMed: 17909493) »
  • Cruciani V & Mikalsen SO Ilimaquinone inhibits gap junctional communication in a connexin isotype-specific manner. Exp Cell Res 304:136-48 (2005). Read more (PubMed: 15707581) »
  • Veit B  et al. Microtubule independent vesiculation of Golgi membranes and the reassembly of vesicles into Golgi stacks. J Cell Biol 122:1197-206 (1993). Read more (PubMed: 8104190) »
  • Takizawa PA  et al. Complete vesiculation of Golgi membranes and inhibition of protein transport by a novel sea sponge metabolite, ilimaquinone. Cell 73:1079-90 (1993). Read more (PubMed: 8513494) »

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