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    ilp2-antibody-ab9664.pdf

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Cell Biology Apoptosis Intracellular Survivin / IAPs
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Anti-ILP2 antibody (ab9664)

  • Datasheet
Submit a review Submit a question References (2)

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Western blot - Anti-ILP2 antibody (ab9664)
  • Immunocytochemistry - Anti-ILP2 antibody (ab9664)

Key features and details

  • Rabbit polyclonal to ILP2
  • Suitable for: WB, ICC
  • Reacts with: Mouse, Human
  • Isotype: IgG

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Secondary
Product image
Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

View more associated products

Overview

  • Product name

    Anti-ILP2 antibody
  • Description

    Rabbit polyclonal to ILP2
  • Host species

    Rabbit
  • Tested Applications & Species

    Application Species
    ICC
    Human
    WB
    Mouse
    Human
    See all applications and species data
  • Immunogen

    Synthetic peptide:

    TGYEARLITFGT

    , corresponding to amino acids 2-13 of Human ILP2. (Peptide available as ab9665.)
    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
  • General notes


    Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family including IAP, XIAP/ILP-1/MIHA, and Livin/KIAP that bind to and inhibits specific proteases. A novel member in the IAP protein family was recently identified and designated ILP-2 for IAP-like protein-2 (1). ILP-2 has high homology to ILP-1, but is encoded by a distinct gene that is solely expressed in testis of tested normal human tissues (1). ILP-2, unlike ILP-1, has no inhibitory effect on Fas and TNF induced apoptosis, but potently inhibits apoptosis induced by overexpression of Bax or by coexpression of caspase-9 with Apaf-1. ILP-2 interacts with the processed caspase-9. These results suggest that ILP-2 is a novel IAP family member with restricted specificity for caspase-9.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer

    pH: 7.2
    Preservative: 0.02% Sodium azide
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Primary antibody notes

    Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family including IAP, XIAP/ILP-1/MIHA, and Livin/KIAP that bind to and inhibits specific proteases. A novel member in the IAP protein family was recently identified and designated ILP-2 for IAP-like protein-2 (1). ILP-2 has high homology to ILP-1, but is encoded by a distinct gene that is solely expressed in testis of tested normal human tissues (1). ILP-2, unlike ILP-1, has no inhibitory effect on Fas and TNF induced apoptosis, but potently inhibits apoptosis induced by overexpression of Bax or by coexpression of caspase-9 with Apaf-1. ILP-2 interacts with the processed caspase-9. These results suggest that ILP-2 is a novel IAP family member with restricted specificity for caspase-9.
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Cell Biology
    • Apoptosis
    • Intracellular
    • Survivin / IAPs
    • Cell Biology
    • Apoptosis
    • Intracellular
    • Caspases etc
    • Inhibitors

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
  • Positive Controls

    • MOLT-4 whole cell lysate (ab7912)
  • Recombinant Protein

    • Recombinant Human ILP2 protein (ab164973)

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab9664 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Guaranteed

Tested applications are guaranteed to work and covered by our Abpromise guarantee.

Predicted

Predicted to work for this combination of applications and species but not guaranteed.

Incompatible

Does not work for this combination of applications and species.

Application Species
ICC
Human
WB
Mouse
Human
Application Abreviews Notes
WB
Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 33 kDa.
ICC
Use a concentration of 10 µg/ml.
Notes
WB
Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 33 kDa.
ICC
Use a concentration of 10 µg/ml.

Target

  • Function

    Protects against apoptosis mediated by BAX.
  • Tissue specificity

    Testis specific in normal tissues.
  • Sequence similarities

    Belongs to the IAP family.
    Contains 1 BIR repeat.
    Contains 1 RING-type zinc finger.
  • Cellular localization

    Cytoplasm.
  • Target information above from: UniProt accession Q96P09 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 112401 Human
    • SwissProt: Q96P09 Human
    • Unigene: 348263 Human
    • Alternative names

      • Baculoviral IAP repeat containing 8 antibody
      • Baculoviral IAP repeat containing protein 8 antibody
      • Baculoviral IAP repeat-containing protein 8 antibody
      • BIRC 8 antibody
      • BIRC8 antibody
      • BIRC8 protein antibody
      • BIRC8_HUMAN antibody
      • hILP 2 antibody
      • hILP2 antibody
      • IAP like protein 2 antibody
      • IAP-like protein 2 antibody
      • ILP 2 antibody
      • ILP-2 antibody
      • Inhibitor of apoptosis like protein 2 antibody
      • Inhibitor of apoptosis-like protein 2 antibody
      • Testis specific inhibitor of apoptosis antibody
      • Testis-specific inhibitor of apoptosis antibody
      see all

    Images

    • Western blot - Anti-ILP2 antibody (ab9664)
      Western blot - Anti-ILP2 antibody (ab9664)

      Western blot analysis of ILP-2 expression in human HepG2 (lane 1) and MOLT4 (lane 2) cell lysates and mouse spleen (lane 3) tissue lysates with anti-ILP-2 at 1 µg/ml.

      Western blot analysis of ILP-2 expression in human HepG2 (lane 1) and MOLT4 (lane 2) cell lysates and mouse spleen (lane 3) tissue lysates with anti-ILP-2 at 1 µg/ml.
    • Immunocytochemistry - Anti-ILP2 antibody (ab9664)
      Immunocytochemistry - Anti-ILP2 antibody (ab9664)

      ab9664 at 10µg/ml staining ILP2 in HepG2 cells by Immunocytochemistry.

    Protocols

    • Western blot protocols

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
  • References (2)

    Publishing research using ab9664? Please let us know so that we can cite the reference in this datasheet.

    ab9664 has been referenced in 2 publications.

    • Kong D  et al. Protective effects of Asiatic acid against pelvic inflammatory disease in rats. Exp Ther Med 17:4687-4692 (2019). PubMed: 31086602
    • Zhu L  et al. Inhibitor of apoptosis protein-like protein-2: A novel growth accelerator for breast cancer cells. Oncol Rep 40:2047-2055 (2018). PubMed: 30106449

    Customer reviews and Q&As

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