Anti-ILT-3 antibody (ab129772)

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Overview

  • Product name

    Anti-ILT-3 antibody
    See all ILT-3 primary antibodies

  • Description

    Rabbit polyclonal to ILT-3

  • Host species

    Rabbit

  • Specificity

    ab129772 detects endogenous levels of total ILT-3 protein.

  • Tested applications

    Suitable for: ELISA, ICC/IFmore details

  • Species reactivity

    Reacts with: Human

  • Immunogen

    Synthetic peptide corresponding to Human ILT-3 (internal sequence).
    Database link: Q8NHJ6

  • Positive control

    • A549 cells

  • General notes

    Previously labelled as LILRB4.

Properties

Applications

Our Abpromise guarantee covers the use of ab129772 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/20000.
ICC/IF 1/100 - 1/500.

Target

  • Function

    Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.

  • Tissue specificity

    Detected in monocytes, macrophages, dendritic cells, lung, natural killer cells and B-cells.

  • Sequence similarities

    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

  • Domain

    Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.

  • Cellular localization

    Cell membrane. Ligand binding leads to internalization and translocation to an antigen-processing compartment.
  • Information by UniProt

  • Database links

    • Alternative names

      • CD85 antigen-like family member K antibody
      • CD85k antibody
      • HM18 antibody
      • ILT-3 antibody
      • ILT3 antibody
      • Immunoglobulin-like transcript 3 antibody
      • Leukocyte immunoglobulin like receptor subfamily B (with TM and ITIM domains) member 4 antibody
      • Leukocyte immunoglobulin-like receptor 5 antibody
      • Leukocyte immunoglobulin-like receptor subfamily B member 4 antibody
      • LILRB4 antibody
      • LILRB5 antibody
      • LIR-5 antibody
      • LIR5 antibody
      • LIRB4_HUMAN antibody
      • Monocyte inhibitory receptor HM18 antibody
      see all

    Images

    • Immunocytochemistry/ Immunofluorescence - Anti-ILT-3 antibody (ab129772)
      Immunocytochemistry/ Immunofluorescence - Anti-ILT-3 antibody (ab129772)

      ab129772, at a 1/100 dilution, staining ILT-3 in A549 cells by Immunofluorescence, with (right image) and without (left image) blocking peptide.

    References

    ab129772 has not yet been referenced specifically in any publications.

    Publishing research using ab129772? Please let us know so that we can cite the reference in this datasheet.

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