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    ilt-3-antibody-ab129772.pdf

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Immunology Immune Interventions Transplantation
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Anti-ILT-3 antibody (ab129772)

  • Datasheet
  • SDS
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Immunocytochemistry/ Immunofluorescence - Anti-ILT-3 antibody (ab129772)

    Key features and details

    • Rabbit polyclonal to ILT-3
    • Suitable for: ICC/IF
    • Reacts with: Human
    • Isotype: IgG

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    Secondary
    Product image
    Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

    View more associated products

    Overview

    • Product name

      Anti-ILT-3 antibody
      See all ILT-3 primary antibodies
    • Description

      Rabbit polyclonal to ILT-3
    • Host species

      Rabbit
    • Specificity

      ab129772 detects endogenous levels of total ILT-3 protein.
    • Tested Applications & Species

      Application Species
      ICC/IF
      Human
      See all applications and species data
    • Immunogen

      Synthetic peptide corresponding to Human ILT-3 (internal sequence).
      Database link: Q8NHJ6

    • Positive control

      • A549 cells
    • General notes

      Previously labelled as LILRB4.

    Properties

    • Form

      Liquid
    • Storage instructions

      Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
    • Storage buffer

      pH: 7
      Preservative: 0.02% Sodium azide
      Constituents: 48% PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride

      PBS does not contain Mg2+ or Ca2+
    • Concentration information loading...
    • Purity

      Immunogen affinity purified
    • Purification notes

      ab129772 was affinity purified from rabbit antiserum by affinity chromatography using epitope specific immunogen.
    • Clonality

      Polyclonal
    • Isotype

      IgG
    • Research areas

      • Immunology
      • Immune Interventions
      • Transplantation
      • Immunology
      • Immunoglobulins
      • Receptors
      • Immunology
      • Adaptive Immunity
      • MHC
      • Class I
      • Epigenetics and Nuclear Signaling
      • Nuclear Signaling Pathways
      • NFkB pathway
      • Cardiovascular
      • Blood
      • Blood Cell Antigens
      • WBC Antigens
      • HLA

    Associated products

    • Compatible Secondaries

      • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
      • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
    • Isotype control

      • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
    • Recombinant Protein

      • Recombinant Human ILT-3 protein (Fc Chimera) (ab179985)

    Applications

    The Abpromise guarantee

    Our Abpromise guarantee covers the use of ab129772 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Guaranteed

    Tested applications are guaranteed to work and covered by our Abpromise guarantee.

    Predicted

    Predicted to work for this combination of applications and species but not guaranteed.

    Incompatible

    Does not work for this combination of applications and species.

    Application Species
    ICC/IF
    Human
    Application Abreviews Notes
    ICC/IF
    1/100 - 1/500.
    Notes
    ICC/IF
    1/100 - 1/500.

    Target

    • Function

      Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
    • Tissue specificity

      Detected in monocytes, macrophages, dendritic cells, lung, natural killer cells and B-cells.
    • Sequence similarities

      Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
    • Domain

      Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
    • Cellular localization

      Cell membrane. Ligand binding leads to internalization and translocation to an antigen-processing compartment.
    • Target information above from: UniProt accession Q8NHJ6 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 11006 Human
      • Omim: 604821 Human
      • SwissProt: Q8NHJ6 Human
      • Unigene: 67846 Human
      • Alternative names

        • CD85 antigen-like family member K antibody
        • CD85k antibody
        • HM18 antibody
        • ILT-3 antibody
        • ILT3 antibody
        • Immunoglobulin-like transcript 3 antibody
        • Leukocyte immunoglobulin like receptor subfamily B (with TM and ITIM domains) member 4 antibody
        • Leukocyte immunoglobulin-like receptor 5 antibody
        • Leukocyte immunoglobulin-like receptor subfamily B member 4 antibody
        • LILRB4 antibody
        • LILRB5 antibody
        • LIR-5 antibody
        • LIR5 antibody
        • LIRB4_HUMAN antibody
        • Monocyte inhibitory receptor HM18 antibody
        see all

      Images

      • Immunocytochemistry/ Immunofluorescence - Anti-ILT-3 antibody (ab129772)
        Immunocytochemistry/ Immunofluorescence - Anti-ILT-3 antibody (ab129772)

        ab129772, at a 1/100 dilution, staining ILT-3 in A549 cells by Immunofluorescence, with (right image) and without (left image) blocking peptide.

      Protocols

      • Immunocytochemistry & immunofluorescence protocols

      Click here to view the general protocols

      Datasheets and documents

      • Datasheet
      • SDS
    • References (0)

      Publishing research using ab129772? Please let us know so that we can cite the reference in this datasheet.

      ab129772 has not yet been referenced specifically in any publications.

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