Anti-ILT-3 antibody (ab129772)
Key features and details
- Rabbit polyclonal to ILT-3
- Suitable for: ICC/IF
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-ILT-3 antibody
See all ILT-3 primary antibodies -
Description
Rabbit polyclonal to ILT-3 -
Host species
Rabbit -
Specificity
ab129772 detects endogenous levels of total ILT-3 protein. -
Tested Applications & Species
See all applications and species dataApplication Species ICC/IF Human
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Immunogen
Synthetic peptide corresponding to Human ILT-3 (internal sequence).
Database link: Q8NHJ6 -
Positive control
- A549 cells
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General notes
Previously labelled as LILRB4.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
Storage buffer
pH: 7
Preservative: 0.02% Sodium azide
Constituents: 48% PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
PBS does not contain Mg2+ or Ca2+ -
Concentration information loading... -
Purity
Immunogen affinity purified -
Purification notes
ab129772 was affinity purified from rabbit antiserum by affinity chromatography using epitope specific immunogen. -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab129772 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Tested applications are guaranteed to work and covered by our Abpromise guarantee.
Predicted to work for this combination of applications and species but not guaranteed.
Does not work for this combination of applications and species.
| Application | Species |
|---|---|
| ICC/IF |
Human
|
| Application | Abreviews | Notes |
|---|---|---|
| ICC/IF |
1/100 - 1/500.
|
| Notes |
|---|
|
ICC/IF
1/100 - 1/500. |
Target
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Function
Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. -
Tissue specificity
Detected in monocytes, macrophages, dendritic cells, lung, natural killer cells and B-cells. -
Sequence similarities
Contains 2 Ig-like C2-type (immunoglobulin-like) domains. -
Domain
Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases. -
Cellular localization
Cell membrane. Ligand binding leads to internalization and translocation to an antigen-processing compartment. - Information by UniProt
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Database links
- Entrez Gene: 11006 Human
- Omim: 604821 Human
- SwissProt: Q8NHJ6 Human
- Unigene: 67846 Human
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Alternative names
- CD85 antigen-like family member K antibody
- CD85k antibody
- HM18 antibody
see all
Images
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Immunocytochemistry/ Immunofluorescence - Anti-ILT-3 antibody (ab129772)
ab129772, at a 1/100 dilution, staining ILT-3 in A549 cells by Immunofluorescence, with (right image) and without (left image) blocking peptide.
Protocols
References (0)
ab129772 has not yet been referenced specifically in any publications.
