Overview

  • Product name
    Anti-ILT-3 antibody - N-terminal
    See all ILT-3 primary antibodies
  • Description
    Rabbit polyclonal to ILT-3 - N-terminal
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human ILT-3 aa 43-73 (N terminal) conjugated to keyhole limpet haemocyanin. The exact sequence is proprietary.
    Database link: Q8NHJ6

  • Positive control
    • MDA-MB435 cell lysate.
  • General notes

    Previously labelled as LILRB4.

Properties

Applications

Our Abpromise guarantee covers the use of ab170669 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 59 kDa.

Target

  • Function
    Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
  • Tissue specificity
    Detected in monocytes, macrophages, dendritic cells, lung, natural killer cells and B-cells.
  • Sequence similarities
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Domain
    Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Cellular localization
    Cell membrane. Ligand binding leads to internalization and translocation to an antigen-processing compartment.
  • Information by UniProt
  • Database links
  • Alternative names
    • CD85 antigen-like family member K antibody
    • CD85k antibody
    • HM18 antibody
    • ILT-3 antibody
    • ILT3 antibody
    • Immunoglobulin-like transcript 3 antibody
    • Leukocyte immunoglobulin like receptor subfamily B (with TM and ITIM domains) member 4 antibody
    • Leukocyte immunoglobulin-like receptor 5 antibody
    • Leukocyte immunoglobulin-like receptor subfamily B member 4 antibody
    • LILRB4 antibody
    • LILRB5 antibody
    • LIR-5 antibody
    • LIR5 antibody
    • LIRB4_HUMAN antibody
    • Monocyte inhibitory receptor HM18 antibody
    see all

Images

  • Anti-ILT-3 antibody - N-terminal (ab170669) at 1/100 dilution + MDA-MB435 cell lysate at 35 µg

    Predicted band size: 59 kDa

References

ab170669 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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