IM 54 (2-(1H-Indol-3-yl)-3-pentylamino-maleimide), Necrosis inhibitor (ab145231)

Overview

  • Product name

    IM 54 (2-(1H-Indol-3-yl)-3-pentylamino-maleimide), Necrosis inhibitor
  • Description

    Potent, selective necrosis inhibitor
  • Alternative names

    • 2-(1H-Indol-3-yl)-3-pentylamino-maleimide
  • Biological description

    Potent, selective necrosis inhibitor (IC50 = 3 μM, H2O2 exposed HeLa cells). Reduces oxidative stress-induced necrosis without effecting anticancer drug-induced apoptosis. Inhibits oxidative stress-induced necrotic cell death in vivo.
  • Purity

    > 98%
  • CAS Number

    861891-50-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1-Methyl-3-(1-methylindol-3-yl)-4-(pentylamino)pyrrole-2,5-dione
  • Molecular weight

    325.40
  • Molecular formula

    C19H23N3O2
  • PubChem identifier

    16760577
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol to 25 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCCCCNC1=C(C(=O)N(C1=O)C)C2=CN(C3=CC=CC=C32)C
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • de Araujo CB  et al. A novel intracellular peptide derived from g1/s cyclin d2 induces cell death. J Biol Chem 289:16711-26 (2014). Read more (PubMed: 24764300) »
  • Li FC  et al. Bioenergetics failure and oxidative stress in brain stem mediates cardiovascular collapse associated with fatal methamphetamine intoxication. PLoS One 7:e30589 (2012). Read more (PubMed: 22276218) »
  • Sodeoka M & Dodo K Development of selective inhibitors of necrosis. Chem Rec 10:308-14 (2010). Read more (PubMed: 20848666) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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