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    imatinib-mesylate-tyrosine-kinase-inhibitor-ab142070.pdf

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Imatinib mesylate, Tyrosine kinase inhibitor (ab142070)

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Chemical Structure - Imatinib mesylate, Tyrosine kinase inhibitor (ab142070)

    Key features and details

    • Potent, selective tyrosine kinase inhibitor
    • CAS Number: 220127-57-1
    • Purity: > 98%
    • Soluble in water to 100 mM and in DMSO to 100 mM
    • Form / State: Solid
    • Source: Synthetic

    Overview

    • Product name

      Imatinib mesylate, Tyrosine kinase inhibitor
    • Description

      Potent, selective tyrosine kinase inhibitor
    • Alternative names

      • 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-phenyl]benzamide methanesulfonate
      • CGP 57148
      • CGP 57148B
      • Genfatinib
      • Gleevec
      • Glivec
      • Imatinib methanesulfonate
      • STI-571
      see all
    • Biological description

      Potent, selective inhibitor of tyrosine kinases v-Abl (IC50 = 38 nM), PDGFR and c-kit. Potent inhibitor of the Bcr-Abl tyrosine kinase created by the Philadelphia chromosome abnormality found in CML. Decreases proliferation and enhances apoptosis in leukemias CML and ALL. 

    • Purity

      > 98%
    • CAS Number

      220127-57-1
    • Chemical structure

      Chemical Structure

    Properties

    • Chemical name

      4-[(4-Methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide mesylate
    • Molecular weight

      589.73
    • Molecular formula

      C29H31N7O.CH4SO3
    • PubChem identifier

      123596
    • Storage instructions

      Shipped at Room Temperature. Store at -20°C. Store under desiccating conditions.
    • Solubility overview

      Soluble in water to 100 mM and in DMSO to 100 mM
    • Handling

      Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

      Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

    • SMILES

      CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC=CC(=N4)C5=CN=CC=C5.CS(=O)(=O)O
    • Source

      Synthetic

    • Research areas

      • Cardiovascular
      • Angiogenesis
      • Growth Factors
      • Other
      • Neuroscience
      • Neurotransmission
      • Receptors / Channels
      • Potassium Channels
      • Immunology
      • Innate Immunity
      • Macrophage / Inflamm.
      • Immunology
      • Cell Type Markers
      • CD
      • Cytokines
      • Tags & Cell Markers
      • Cell Type Markers
      • Tumor Associated
      • Epigenetics and Nuclear Signaling
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      • DNA Damage & Repair
      • Homologous Recomb.
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      • DNA / RNA
      • DNA Synthesis
      • Topoisomerases
      • Epigenetics and Nuclear Signaling
      • Transcription
      • Domain Families
      • Zinc Finger
      • Neuroscience
      • Neurology process
      • Neural Signal Transduction
      • Signal Transduction
      • Protein Phosphorylation
      • Tyrosine Kinases
      • Other
      • Signal Transduction
      • Protein Phosphorylation
      • Ser / Thr Kinases
      • Other Kinases
      • Signal Transduction
      • Signaling Pathway
      • G Protein Signaling
      • Small G Proteins
      • Ras Family
      • Signal Transduction
      • Protein Phosphorylation
      • Tyrosine Kinases
      • Receptor Tyrosine Kinases
      • Epigenetics and Nuclear Signaling
      • Transcription
      • Domain Families
      • HLH / Leucine Zipper
      • Helix-Turn-Helix
      • Signal Transduction
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      • Nuclear Hormone Receptors
      • Progesterone
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      • Signaling Pathway
      • Nuclear Signaling
      • Nuclear Hormone Receptors
      • Estrogen
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      • Signaling Pathway
      • Nuclear Signaling
      • Nuclear Hormone Receptors
      • Testosterone
      • Signal Transduction
      • Growth Factors/Hormones
      • PDGF
      • Signal Transduction
      • Growth Factors/Hormones
      • Hormones
      • Signal Transduction
      • Metabolism
      • Energy Metabolism
      • Signal Transduction
      • Metabolism
      • Plasma Membrane
      • Channels
      • Neuroscience
      • Endocrine system
      • Thyroid axis
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      • Endocrine system
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      • Epigenetics and Nuclear Signaling
      • Transcription
      • Cancer susceptibility
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      • Estrogen
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      • Progesterone
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      • Nuclear Receptors
      • Retinoic & Retinoid
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      • Nuclear Signaling Pathways
      • Nuclear Receptors
      • Testosterone
      • Stem Cells
      • Germline Stem Cells
      • Embryonic Germ Cells
      • Stem Cells
      • Hematopoietic Progenitors
      • Surface Molecules
      • Epigenetics and Nuclear Signaling
      • Transcription
      • Transcription Factors
      • Epigenetics and Nuclear Signaling
      • Nuclear Signaling Pathways
      • Nuclear Receptors
      • Orphan Nuclear Receptors
      • Signal Transduction
      • Metabolism
      • Drug metabolism
      • Stem Cells
      • Signaling Pathways
      • Hedgehog
      • Nuclear
      • Cancer
      • Growth factors
      • PDGF
      • Cancer
      • Signal transduction
      • Nuclear signaling
      • Nuclear hormone receptors
      • Estrogen
      • Cancer
      • Signal transduction
      • Nuclear signaling
      • Nuclear hormone receptors
      • Progesterone
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      • Signal transduction
      • Nuclear signaling
      • Nuclear hormone receptors
      • Other
      • Cancer
      • Signal transduction
      • Protein phosphorylation
      • Serine/threonine kinases
      • Other
      • Cancer
      • Oncoproteins/suppressors
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      • Oncoproteins
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      • Atherosclerosis
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      • Inflammatory mediators
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      • Blood Pressure regulation
      • Cardiovascular
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      • Vasoconstriction
      • Other
      • Cardiovascular
      • Vasculature
      • Vasodilation
      • Other
      • Stem Cells
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      • Myeloid
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      • Molecular processes
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      • Metabolic signaling pathways
      • Lipid and lipoprotein metabolism
      • Lipid metabolism
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      • Metabolic signaling pathways
      • Drug metabolism
      • Metabolism
      • Pathways and Processes
      • Metabolic signaling pathways
      • Energy transfer pathways
      • Energy Metabolism
      • Metabolism
      • Pathways and Processes
      • Metabolism processes
      • Hypoxia

    Images

    • Chemical Structure - Imatinib mesylate, Tyrosine kinase inhibitor (ab142070)
      Chemical Structure - Imatinib mesylate, Tyrosine kinase inhibitor (ab142070)
      2D chemical structure image of ab142070, Imatinib mesylate, Tyrosine kinase inhibitor

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download

    References (2)

    Publishing research using ab142070? Please let us know so that we can cite the reference in this datasheet.

    ab142070 has been referenced in 2 publications.

    • Higa-Nakamine S  et al. Fyn-mediated phosphorylation of Pyk2 promotes its activation and dissociation downstream of gonadotropin-releasing hormone receptor. FEBS J 287:3551-3564 (2020). PubMed: 31994829
    • Battaglia CR  et al. Corticotropin-releasing hormone (CRH) alters mitochondrial morphology and function by activating the NF-kB-DRP1 axis in hippocampal neurons. Cell Death Dis 11:1004 (2020). PubMed: 33230105

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