Imatinib mesylate, Tyrosine kinase inhibitor (ab142070)

Overview

  • Product name

    Imatinib mesylate, Tyrosine kinase inhibitor
  • Description

    Potent, selective tyrosine kinase inhibitor
  • Alternative names

    • 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-phenyl]benzamide methanesulfonate
    • CGP 57148
    • CGP 57148B
    • Genfatinib
    • Gleevec
    • Glivec
    • Imatinib methanesulfonate
    • STI-571
    see all
  • Biological description

    Potent, selective inhibitor of tyrosine kinases v-Abl (IC50 = 38 nM), PDGFR and c-kit. Potent inhibitor of the Bcr-Abl tyrosine kinase created by the Philadelphia chromosome abnormality found in CML. Decreases proliferation and enhances apoptosis in leukemias CML and ALL. 

  • Purity

    > 98%
  • CAS Number

    220127-57-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    4-[(4-Methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide mesylate
  • Molecular weight

    589.73
  • Molecular formula

    C29H31N7O.CH4SO3
  • PubChem identifier

    123596
  • Storage instructions

    Shipped at Room Temperature. Store at -20°C. Store under desiccating conditions.
  • Solubility overview

    Soluble in water to 100 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC=CC(=N4)C5=CN=CC=C5.CS(=O)(=O)O
  • Source

    Synthetic

References

This product has been referenced in:

  • Corbin AS  et al. Several Bcr-Abl kinase domain mutants associated with imatinib mesylate resistance remain sensitive to imatinib. Blood 101:4611-4 (2003). Read more (PubMed: 12576318) »
  • Krystal GW Mechanisms of resistance to imatinib (STI571) and prospects for combination with conventional chemotherapeutic agents. Drug Resist Updat 4:16-21 (2001). Read more (PubMed: 11512148) »
  • Heinrich MC  et al. Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor. Blood 96:925-32 (2000). Read more (PubMed: 10910906) »
  • Buchdunger E  et al. Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative. Cancer Res 56:100-4 (1996). Read more (PubMed: 8548747) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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