Overview

  • Product name

    IMD 0354, IKKbeta inhibitor
  • Description

    Potent, selective cell-permeable IKKβ inhibitor
  • Biological description

    Potent, selective cell-permeable IKKβ inhibitor (IC50 = 250 nM). Blocks IκBα phosphorylation and prevents NF-κB p65 nuclear translocation. Reduces IL-1β and MCP-1 production. Shows antiproliferative effects. Shows anti-inflammatory effects in vivo.
  • Purity

    > 99%
  • CAS Number

    978-62-1
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Lennikov A  et al. I?B kinase-ß inhibitor IMD-0354 beneficially suppresses retinal vascular permeability in streptozotocin-induced diabetic mice. Invest Ophthalmol Vis Sci 55:6365-73 (2014). Read more (PubMed: 25205865) »
  • Liu C  et al. Central IKKß inhibition prevents air pollution mediated peripheral inflammation and exaggeration of type II diabetes. Part Fibre Toxicol 11:53 (2014). Read more (PubMed: 25358444) »
  • Tanaka A  et al. A novel NF-kappaB inhibitor, IMD-0354, suppresses neoplastic proliferation of human mast cells with constitutively activated c-kit receptors. Blood 105:2324-31 (2005). Read more (PubMed: 15561889) »

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