IMD 0354, IKKbeta inhibitor (ab144823)
Key features and details
- Potent, selective cell-permeable IKKβ inhibitor
- CAS Number: 978-62-1
- Purity: > 98%
Soluble in ethanol to 7.74 mM and in DMSO to 262.73 mM
- Form / State: Solid
- Source: Synthetic
Overview
-
Product name
IMD 0354, IKKbeta inhibitor -
Description
Potent, selective cell-permeable IKKβ inhibitor -
Biological description
Potent, selective cell-permeable IKKβ inhibitor (IC50 = 250 nM). Blocks IκBα phosphorylation and prevents NF-κB p65 nuclear translocation. Reduces IL-1β and MCP-1 production. Shows antiproliferative effects. Shows anti-inflammatory effects in vivo. -
Purity
> 98% -
CAS Number
978-62-1 -
Chemical structure
Properties
-
Chemical name
N-[3,5-Bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide
-
Molecular weight
383.67 -
PubChem identifier
5081913 -
Storage instructions
Store at -20°C (desiccating conditions). -
Solubility overview
Soluble in ethanol to 7.74 mM and in DMSO to 262.73 mM
-
Handling
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
Oc2ccc(Cl)cc2C(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F -
Source
Synthetic
-
Research areas
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
-
SDS download
-
Datasheet download
References (3)
ab144823 has been referenced in 3 publications.
- Cuaycal AE et al. Lactobacillus johnsonii N6.2 phospholipids induce immature-like dendritic cells with a migratory-regulatory-like transcriptional signature. Gut Microbes 15:2252447 (2023). PubMed: 37675983
- Sheng J et al. Treatment of Retinoblastoma 1-Intact Hepatocellular Carcinoma With Cyclin-Dependent Kinase 4/6 Inhibitor Combination Therapy. Hepatology 74:1971-1993 (2021). PubMed: 33931882
- Miyagawa Y et al. Evaluation of cancer-derived myocardial impairments using a mouse model. Oncotarget 11:3712-3722 (2020). PubMed: 33110478