Overview

  • Product name

    Imipenem, beta-lactam antibiotic
  • Description

    Highly potent, broad spectrum β-lactam antibiotic
  • Biological description

    Highly potent, broad spectrum β-lactam antibiotic (IC50 = 0.15 μM). Bactericidal effect and capable of interacting with GABAA receptors. Modest penetration of the BBB.
  • Purity

    > 95%
  • CAS Number

    64221-86-9
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Kotsakis SD  et al. GES-13, a beta-lactamase variant possessing Lys-104 and Asn-170 in Pseudomonas aeruginosa. Antimicrob Agents Chemother 54:1331-3 (2010). Read more (PubMed: 20065056) »
  • Bernabeu-Wittel M  et al. Pharmacokinetic/pharmacodynamic assessment of the in-vivo efficacy of imipenem alone or in combination with amikacin for the treatment of experimental multiresistant Acinetobacter baumannii pneumonia. Clin Microbiol Infect 11:319-25 (2005). Read more (PubMed: 15760430) »
  • Dupuis A  et al. Pharmacokinetic-pharmacodynamic modeling of the electroencephalogram effect of imipenem in healthy rats. Antimicrob Agents Chemother 45:1682-7 (2001). Read more (PubMed: 11353611) »
  • Kropp H  et al. Antibacterial activity of imipenem: the first thienamycin antibiotic. Rev Infect Dis 7 Suppl 3:S389-410 (0). Read more (PubMed: 3931196) »

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