Overview

  • Product name

    Imipramine hydrochloride, Tricyclic antidepressant
  • Description

    Tricyclic antidepressant
  • Alternative names

    • Imipramine
  • Biological description

    Tricyclic antidepressant with various pharmacological activities. Inhibits reuptake inhibitors (Ki values are 19, 98 and >1000 nM for SERT, NET and DAT, respectively). Muscarinic receptor inhibitor (IC50 = 0.13 μM for M2). Serotonin receptor inhibitor (Ki values are 94 and 160 nM for 5-HT2A and 5-HT2C, respectively). Crosses the blood-brain barrier.
  • Purity

    > 98%
  • CAS Number

    113-52-0
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Patel S  et al. Simultaneous spectrophotometric estimation of imipramine hydrochloride and chlordiazepoxide in tablets. Indian J Pharm Sci 71:468-72 (2009). Read more (PubMed: 20502561) »
  • Bymaster FP  et al. Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder. Neuropsychopharmacology 27:699-711 (2002). Read more (PubMed: 12431845) »
  • Runyon SP  et al. Influence of chain length and N-alkylation on the selective serotonin receptor ligand 9-(aminomethyl)-9,10-dihydroanthracene. Bioorg Med Chem Lett 11:655-8 (2001). Read more (PubMed: 11266163) »
  • Kovacs I  et al. Pharmacological comparison of the cloned human and rat M2 muscarinic receptor genes expressed in the murine fibroblast (B82) cell line. J Pharmacol Exp Ther 284:500-7 (1998). Read more (PubMed: 9454790) »
  • Seelig A  et al. A method to determine the ability of drugs to diffuse through the blood-brain barrier. Proc Natl Acad Sci U S A 91:68-72 (1994). Read more (PubMed: 8278409) »

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