Overview

  • Product name

  • Description

    Rabbit polyclonal to IMPDH1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Cow
  • Immunogen

    Recombinant fragment within Human IMPDH1 (internal sequence). The exact sequence is proprietary.
    Database link: P20839

  • Positive control

    • WB: Raji whole cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab228002 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 55 kDa.

Target

  • Function

    Rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth. It may also have a role in the development of malignancy and the growth progression of some tumors.
  • Tissue specificity

    IMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor.
  • Pathway

    Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.
  • Involvement in disease

    Defects in IMPDH1 are the cause of retinitis pigmentosa type 10 (RP10) [MIM:180105]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP10 inheritance is autosomal dominant.
  • Sequence similarities

    Belongs to the IMPDH/GMPR family.
    Contains 2 CBS domains.
  • Information by UniProt
  • Database links

  • Alternative names

    • IMDH1_HUMAN antibody
    • IMP (inosine monophosphate) dehydrogenase 1 antibody
    • IMP dehydrogenase 1 antibody
    • IMPD 1 antibody
    • IMPD antibody
    • IMPD1 antibody
    • IMPDH 1 antibody
    • IMPDH I antibody
    • IMPDH-I antibody
    • Impdh1 antibody
    • Inosine 5' monophosphate dehydrogenase 1 antibody
    • Inosine monophosphate dehydrogenase 1 antibody
    • Inosine-5''-monophosphate dehydrogenase 1 antibody
    • LCA11 antibody
    • RP10 antibody
    • sWSS2608 antibody
    see all

Images

  • Anti-IMPDH1 antibody (ab228002) at 1/1000 dilution + Raji (human Burkitt's lymphoma cell line) whole cell lysate at 30 µg

    Predicted band size: 55 kDa



    7.5% SDS-PAGE gel.

References

ab228002 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab228002.
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