Overview

  • Product name

    Imperatorin, Cyclin D1 inhibitor
  • Description

    Cyclin D1 inhibitor
  • Biological description

    Cyclin D1 inhibitor. Induces cell cycle arrest at G1. Activates caspase 9 and induces apoptosis. Inhibits HIV-1 replication. Weak TRPV1 agonist (EC50 = 13 μM). Shows antiproliferative effects. Shows analgesic effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    482-44-0
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Chen X  et al. Furanocoumarins are a novel class of modulators for the transient receptor potential vanilloid type 1 (TRPV1) channel. J Biol Chem 289:9600-10 (2014). Read more (PubMed: 24569998) »
  • Badziul D  et al. Combined treatment with quercetin and imperatorin as a potent strategy for killing HeLa and Hep-2 cells. Mol Cell Biochem : (2014). Read more (PubMed: 24682729) »
  • Sancho R  et al. Imperatorin inhibits HIV-1 replication through an Sp1-dependent pathway. J Biol Chem 279:37349-59 (2004). Read more (PubMed: 15218031) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab143498.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up