Overview

  • Product name
    Anti-Importin 9/RANBP9 antibody - C-terminal
    See all Importin 9/RANBP9 primary antibodies
  • Description
    Rabbit polyclonal to Importin 9/RANBP9 - C-terminal
  • Host species
    Rabbit
  • Specificity

    ab198782 detects endogenous levels of total Importin 9/RANBP9 protein.

  • Tested applications
    Suitable for: IHC-P, WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide corresponding to Human Importin 9/RANBP9 (C terminal). NP_060555.
    Database link: Q96P70

  • Positive control
    • Human fetal brain and HeLa lysates; Human thyroid cancer tissue.
  • General notes

     This product was previously labelled as Importin 9

     

Properties

Applications

Our Abpromise guarantee covers the use of ab198782 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/200.
WB 1/200 - 1/1000. Predicted molecular weight: 116 kDa.

Target

  • Function
    Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of H2B histone (By similarity), RPS7 and RPL18A. Prevents the cytoplasmic aggregation of RPS7 and RPL18A by shielding exposed basic domains. May also import H2A, H3, H4 histones (By similarity), RPL4 and RPL6.
  • Sequence similarities
    Belongs to the importin beta family.
    Contains 1 importin N-terminal domain.
  • Cellular localization
    Cytoplasm. Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • Imp9 antibody
    • Imp9a antibody
    • Imp9b antibody
    • Importin-9 antibody
    • Importin-9a antibody
    • Ipo9 antibody
    • IPO9_HUMAN antibody
    • Ran-binding protein 9 antibody
    • RanBP9 antibody
    see all

Images

  • All lanes : Anti-Importin 9/RANBP9 antibody - C-terminal (ab198782) at 1/200 dilution

    Lane 1 : Human fetal brain lysate
    Lane 2 : HeLa cell lysate

    Lysates/proteins at 40 µg per lane.

    Predicted band size: 116 kDa


    Exposure time: 30 seconds


    6% SDS-PAGE

  • Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue labeling Importin 9/RANBP9 with ab198782 at 1/40 dilution.

References

ab198782 has not yet been referenced specifically in any publications.

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