Key features and details
- Potent, cell-permeable, selective calcineurin-NFAT interaction inhibitor
- CAS Number: 3519-82-2
- Purity: > 97%
- Soluble in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
Product nameINCA-6, calcineurin-NFAT interaction inhibitor
DescriptionPotent, cell-permeable, selective calcineurin-NFAT interaction inhibitor
Potent, cell-permeable, selective calcineurin-NFAT interaction inhibitor (Kd = 800 nM). Blocks NFAT dephosphorylation, cytokine mRNA induction and nuclear import (~40 µM). Unlike CsA (ab120114) and FK506 (ab120223) INCA-6 does not indiscriminately block other calcineurin substrates. Anti-inflammatory agent. Active in vitro and in vivo.
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 25 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab145864 has been referenced in 2 publications.
- Samanta J et al. Oleic Acid Protects from Arsenic-Induced Cardiac Hypertrophy via AMPK/FoxO/NFATc3 Pathway. Cardiovasc Toxicol 20:261-280 (2020). PubMed: 31571030
- Thulin NK et al. Maternal Anti-Dengue IgG Fucosylation Predicts Susceptibility to Dengue Disease in Infants. Cell Rep 31:107642 (2020). PubMed: 32402275