Incadronate (Disodium Cycloheptylaminomethylene diphosphate), bone resorption inhibitor (ab142293)

Overview

  • Product name

    Incadronate (Disodium Cycloheptylaminomethylene diphosphate), bone resorption inhibitor
  • Description

    Bone resorption inhibitor
  • Alternative names

    • Disodium Cycloheptylaminomethylene diphosphate
  • Biological description

    Bone resorption inhibitor. Inhibits macrophage migration to site of inflammation in vivo. Inhibits proliferation and causes apoptosis in cancer cells in vitro. Bone density conservation, antitumor and anti-inflammatory agent.
  • Purity

    > 98%
  • CAS Number

    138330-18-4
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Matsuo A  et al. Antiinflammatory and chondroprotective effects of the aminobisphosphonate incadronate (YM175) in adjuvant induced arthritis. J Rheumatol 30:1280-90 (2003). Read more (PubMed: 12784404) »
  • Shigematsu M  et al. New bone-seeking agent: animal study of Tc-99m-incadronate. Ann Nucl Med 16:55-9 (2002). Read more (PubMed: 11922209) »
  • Shipman CM  et al. The bisphosphonate incadronate (YM175) causes apoptosis of human myeloma cells in vitro by inhibiting the mevalonate pathway. Cancer Res 58:5294-7 (1998). Read more (PubMed: 9850051) »

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