Integrin signaling in shear stress-induced endothelial cell dysfunction

Download a copy of our new pathway card, 'Integrin signaling', or request a hardcopy for your lab.

Integrin signaling card

The integrin family of transmembrane proteins consists of 18 alpha and eight beta subunits which form 24 different heterodimeric complexes, serving as receptors for extracellular matrix (ECM) or cell surface molecules. Integrins link the cytoskeleton to the ECM, essential for vascular smooth muscle cell migration in atherosclerosis. Matrix remodeling and changing tissue stiffness regulates integrin signaling and cell proliferation in cardiovascular biology and disease.

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Related products

Integrin alpha 5 (ab6131)

ab6131
Clonality
M
Applications
Flow Cyt, ICC/IF, IP
Reactivity
Hu

View Integrin alpha 5 (ab6131)

Integrin B antibody (ab52971)

ab52971
Clonality
P
Applications
Flow Cyt, ICC/IF, IHC-Fr, IHC-P, IHC-P, WB
Reactivity
Hu, Ms, Rat

View Integrin B antibody (ab52971)

Laminin antibody (ab11575)

ab11575
Clonality
P
Applications
Dot, ICC/IF, IHC-FoFr, IHC-Fr, IHC-P, IP
Reactivity
Hu, Ms, Dog, Pig, Xl

View Laminin antibody (ab11575)

PAK1 antibody (ab40795)

ab40795
Clonality
M
Applications
ICC/IF, IHC-P, IP, WB
Reactivity
Hu, Ms, Rat

View PAK1 antibody (ab40795)

Other Integrin related antibodies

Product name

Applications

Antibody code

Collagen IV

IHC-P, IHC-FoFr, IP, WB, ELISA, IHC-Fr

ab6586

Fibrinogen

IHC-P, ELISA, ICC/IF, FuncS 

ab34269

Fibronectin

AP, ICC/IF, IHC-Fr, IHC-P, RIA, WB

ab6328

FLk1 / VEGF Receptor 2

IP, Flow Cyt, IHC-P, ICC/IF, IHC-Fr 

ab2349

ICAM1

ELISA, Flow Cyt, IP, WB

ab2213

IKK alpha + IKK beta

IHC-P, ELISA

ab62481

Integrin alpha 2

IP, Flow Cyt, IHC-P, IHC-Fr 

ab10800

Integrin alpha 2 + beta 1

Flow Cyt, IP, WB, ELISA, ICC/IF, IHC-Fr 

ab30483

Integrin alpha 5

Flow Cyt, ICC/IF, IP

ab6131

Integrin alpha 5 + beta 1

Flow Cyt, IP, Inhib, WB, IHC-Fr 

ab77981

Integrin alpha v

ELISA, Flow Cyt, ICC/IF, IHC-P, IP

ab16821

Integrin alpha v + beta 3

BL, IP, IHC-Fr 

ab78289

Integrin beta 1

Flow Cyt, ICC/IF, IHC-Fr, IHC-P, IHC-P, WB

ab52971

Integrin beta 3

Flow Cyt, ICC/IF, IHC-Fr, IHC-P, IP, Inhib, WB

ab7167

JNK1+JNK2 (phospho T183+Y185)

IHC-P, WB, ICC/IF, IHC-Fr 

ab4821

JNK1+JNK2+JNK3

WB, ELISA

ab59227

Laminin

Dot, ICC/IF, IHC-FoFr, IHC-Fr, IHC-P, IP

ab11575

MKK4 / MEK4 (phospho S80)

IHC-P, WB, ELISA

ab39403

NFkB

ChIP, EMSA, ICC/IF, IHC-Fr, IHC-P, IP, WB

ab7970

PAK1

ICC/IF, IHC-P, IP, WB

ab40795

PAK1+PAK2+PAK3

IHC-P, ELISA

ab59248

PECAM1 / CD31

IP, WB, ICC/IF 

ab24590

PECAM1 / CD31 (APC)

BL, Flow Cyt, IP, IHC-Fr 

ab25563

PI 3 Kinase p85 alpha

Flow Cyt, ICC/IF, IHC-P, IP, WB

ab40755

Rac1

IHC-P, WB, ICC/IF 

ab78139

Rac2

IHC-P, WB, ELISA

ab2244

Src

IHC-P, WB, ELISA, ICC/IF 

ab47405

Src (phospho Y529)

IP, WB, ICC/IF, Dot 

ab32078

VCAM1 (FITC)

Flow Cyt, ICC/IF, FuncS, IP 

ab24853

VE cadherin

Flow Cyt, IHC-P, IHC-Fr, IP, Neut, WB, P, ICC/IF 

ab7047

 

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