Overview

  • Product name

    Indinavir sulfate, antiviral HIV protease inhibitor
  • Description

    Hydroxyaminopentane amide antiretroviral protease inhibitor
  • Biological description

    Hydroxyaminopentane amide antiretroviral protease inhibitor. Inhibits HIV-1 protease and suppresses HIV replication in vivo. Induces glutathione export from astrocytes. Orally active.
  • Purity

    > 98%
  • CAS Number

    157810-81-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (2S)-1-[(2S,4R)-4-Benzyl-2-hydroxy-5-[[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-5-oxopentyl]-N-tert-butyl-4-(pyridin-3-ylmethyl)piperazine-2-carboxamide sulfate
  • Molecular weight

    711.87
  • Molecular formula

    C36H47N5O4.H2SO4
  • PubChem identifier

    5462355
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(C)(C)NC(=O)C1CN(CCN1CC(CC(CC2=CC=CC=C2)C(=O)NC3(CC4=CC=CC=C34)O)O)CC5=CN=CC=C5.OS(=O)(=O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Arend C  et al. The antiretroviral protease inhibitor ritonavir accelerates glutathione export from cultured primary astrocytes. Neurochem Res 38:732-41 (2013). Read more (PubMed: 23341120) »
  • Kanmogne GD  et al. Mononuclear phagocyte intercellular crosstalk facilitates transmission of cell-targeted nanoformulated antiretroviral drugs to human brain endothelial cells. Int J Nanomedicine 7:2373-88 (2012). Read more (PubMed: 22661891) »
  • Toulah FH  et al. Evaluation of garlic plant and indinavir drug efficacy in the treatment of cryptosporidiosis in experimentally immumosuppressed rats. J Egypt Soc Parasitol 42:321-8 (2012). Read more (PubMed: 23214211) »

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