Key features and details
- Potent GSK3β inhibitor. CDK inhibitor.
- CAS Number: 160807-49-8
- Purity: > 98%
- Form / State: Solid
- Source: Synthetic
Product nameIndirubin-3'-monoxime, GSK3beta inhibitor. CDK inhibitor.
DescriptionPotent GSK3β inhibitor. CDK inhibitor.
Biological descriptionPotent GSK3β inhibitor (IC50 = 22 nM). CDK inhibitor (IC50 values are 0.1 (Cdk5/p35), 0.18 (Cdk1/cyclin B), 0.25 (Cdk2/cyclin E), 0.5 (Cdk2/cyclin A) and 3.3 μM (Cdk4/cyclin D1)). Shows reversible antiproliferative effects via G2/M cell cycle arrest. Prevents tau phosphorylation. Shows neuroprotective effects in vivo.
Storage instructionsStore at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab141296 has not yet been referenced specifically in any publications.