Indole-3-carbinol (I3C), Anticancer agent (ab143132)

Overview

  • Product name

    Indole-3-carbinol (I3C), Anticancer agent
  • Description

    Phytochemical. Anticancer agent.
  • Alternative names

    • I3C
  • Biological description

    Phytochemical. Anticancer agent. Induces G1 arrest. Downregulates cell cycle-related proteins (CDK4, CDK6, cyclin D1 and pRb). Active in vitro and in vivo. Blood-brain barrier permeable.
  • CAS Number

    700-06-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1H-Indol-3-ylmethanol
  • Molecular weight

    147.17
  • Molecular formula

    C9H9NO
  • PubChem identifier

    3712
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC=C2C(=C1)C(=CN2)CO
  • Source

    Synthetic

References

This product has been referenced in:

  • Bai LY  et al. OSU-A9, an indole-3-carbinol derivative, induces cytotoxicity in acute myeloid leukemia through reactive oxygen species-mediated apoptosis. Biochem Pharmacol 86:1430-40 (2013). Read more (PubMed: 24041743) »
  • Chen Z  et al. Indole-3-carbinol inhibits nasopharyngeal carcinoma growth through cell cycle arrest in vivo and in vitro. PLoS One 8:e82288 (2013). Read more (PubMed: 24358165) »

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