Indoximod, Indoleamine 2,3-dioxygenase (IDO) inhibitor (ab231506)

Overview

  • Product name

    Indoximod, Indoleamine 2,3-dioxygenase (IDO) inhibitor
  • Description

    Indoleamine 2,3-dioxygenase (IDO) inhibitor
  • Alternative names

    • 1-methyl-D-tryptophan
    • NLG-8189
  • Biological description

    Methylated tryptophan which acts as an Indoleamine 2,3-dioxygenase (IDO) inhibitor. Prevents T-cell anergy triggered by dendritic cells overexpressing IDO in mice.

  • CAS Number

    110117-83-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (2R)-2-Amino-3-(1-methylindol-3-yl)propanoic acid
  • Molecular weight

    218.26
  • Molecular formula

    C12H14N2O
  • PubChem identifier

    405012
  • Storage instructions

    Shipped at 4°C. Store at -20°C.
  • SMILES

    CN1C=C(C2=CC=CC=C21)C[C@H](C(=O)O)N
  • Source

    Synthetic

References

This product has been referenced in:

  • Hou DY  et al. Inhibition of indoleamine 2,3-dioxygenase in dendritic cells by stereoisomers of 1-methyl-tryptophan correlates with antitumor responses. Cancer Res 67:792-801 (2007). Read more (PubMed: 17234791) »
  • Munn DH  et al. Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes. J Clin Invest 114:280-90 (2004). Read more (PubMed: 15254595) »

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