Overview

  • Product name

    INDY, DYRK1A/B inhibitor
  • Description

    Potent DYRK1A/B inhibitor 
  • Alternative names

    • 1169755-45-6
  • Biological description

    Potent DYRK1A/B inhibitor (IC50 values are 0.23 and 0.24 µM for DYRK1B and DYRK1A respectively). Also inhibits DYRK2, DTRK4, CLK1, CLK4, casein kinase 1 and PIM1 (> 90% inhibition at 10 μM). Reverses aberrant tau-phosphorylation and rescues repressed calcineurin/NFAT signaling. Impairs the self-renewal capacity of neural stem cells and glioblastoma tumor-initiating cells.

  • Purity

    > 98%
  • CAS Number

    1169755-45-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (1Z)-1-(3-Ethyl-5-hydroxy-2(3H)-benzothiazolylidene)-2-propanone
  • Molecular weight

    235.30
  • Molecular formula

    C12H13NO2S
  • PubChem identifier

    69538603
  • Storage instructions

    Shipped at Room Temperature. Store at +4°C short term (1-2 weeks). Store at -20°C.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCN1C2=C(C=CC(=C2)O)SC1=CC(=O)C
  • Source

    Synthetic

References

ab223890 has not yet been referenced specifically in any publications.

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