• Product name

    Anti-INF2 antibody - N-terminal
    See all INF2 primary antibodies
  • Description

    Rabbit polyclonal to INF2 - N-terminal
  • Host species

  • Tested applications

    Suitable for: WB, IPmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Recombinant fragment within Human INF2 (N terminal). The exact sequence is proprietary.
    Database link: Q27J81

  • Positive control

    • WB: HEK-293T, A431, HeLa and HepG2 whole cell extracts. IP: HEK-293T whole cell extract.
  • General notes

     This product was previously labelled as C14orf151




Our Abpromise guarantee covers the use of ab229479 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 136 kDa.
IP 1/100 - 1/500.


  • Function

    Severs actin filaments and accelerates their polymerization and depolymerization.
  • Tissue specificity

    Widely expressed. In the kidney, expression is apparent in podocytes and some tubule cells.
  • Involvement in disease

    Defects in INF2 are the cause of focal segmental glomerulosclerosis type 5 (FSGS5) [MIM:613237]. A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and edema. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation.
  • Sequence similarities

    Belongs to the formin homology family.
    Contains 1 FH2 (formin homology 2) domain.
    Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain.
    Contains 1 WH2 domain.
  • Domain

    The WH2 domain acts as the DAD (diaphanous autoregulatory) domain and binds to actin monomers.
    Regulated by autoinhibition due to intramolecular GBD-DAD binding.
    The severing activity is dependent on covalent attachment of the FH2 domain to the C-terminus.
  • Cellular localization

    Cytoplasm > perinuclear region.
  • Information by UniProt
  • Database links

  • Alternative names

    • C14orf151 antibody
    • C14orf173 antibody
    • CMTDIE antibody
    • DKFZp762A0214 antibody
    • FLJ22056 antibody
    • FSGS5 antibody
    • HBEAG binding protein 2 binding protein C antibody
    • HBEBP2 binding protein C antibody
    • HBEBP2-binding protein C antibody
    • INF 2 antibody
    • inf2 antibody
    • INF2_HUMAN antibody
    • Inverted formin 2 antibody
    • Inverted formin FH2 and WH2 domain containing antibody
    • Inverted formin-2 antibody
    • MGC13251 antibody
    • pp9484 antibody
    see all


  • All lanes : Anti-INF2 antibody - N-terminal (ab229479) at 1/1000 dilution

    Lane 1 : HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell extract
    Lane 2 : A431 (human epidermoid carcinoma cell line) whole cell extract
    Lane 3 : HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell extract
    Lane 4 : HepG2 (human liver hepatocellular carcinoma cell line) whole cell extract

    Lysates/proteins at 30 µg per lane.

    Developed using the ECL technique.

    Predicted band size: 136 kDa

    5% SDS-PAGE

  • INF2 was immunoprecipitated from HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell extract with 5 μg ab229479. Western blot was performed from the immunoprecipitate using ab229479.

    Lane 1: HEK-293T whole cell extract (Input)

    Lane 2: Control IgG IP in HEK-293T whole cell extract.

    Lane 3: ab229479 IP in HEK-293T whole cell extract.


ab229479 has not yet been referenced specifically in any publications.

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