Overview

  • Product name

    Anti-Influenza A Nonstructural Protein 1 antibody
  • Description

    Rabbit polyclonal to Influenza A Nonstructural Protein 1
  • Host species

    Rabbit
  • Specificity

    Specific for the seasonal Influenza A Nonstructural Protein 1. Does not bind the corresponding Nonstructural Protein 1 from the swine flu Influenza A virus.
  • Tested applications

    Suitable for: ELISAmore details
  • Species reactivity

    Reacts with: Influenza A
  • Immunogen

    Synthetic peptide specific for the seasonal Influenza A H1N1 Nonstructural Protein 1 (ABP49398).

Properties

Applications

Our Abpromise guarantee covers the use of ab91642 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent dilution.

Target

  • Relevance

    Influenza A virus is a major public health threat, killing more than 30,000 people per year in the USA. The virus has one of sixteen possible hemagglutinin (HA) surface proteins and one of nine possible neuraminidase (NA) surface proteins. In early 2009, a novel H1N1 swine-origin influenza (S-OIV) A virus was identified in specimens obtained from patients in Mexico and the United States. The genetic make-up of this swine flu virus is unlike any other: it is an H1N1 strain that combines a triple assortment first identified in 1998 including human, swine, and avian influenza with two new pig H3N2 virus genes from Eurasia, themselves of recent human origin. One of the less studied proteins encoded by, but not incorporated in, the influenza virus is the nonstructural protein (NS) 1. NS1 counters cellular antiviral activities and acts as a virulence factor. It can bind to double-stranded RNA and sequester it from 2’-5’ OAS, preventing the activation of the RNAse L, which normally acts to degrade RNA and prevent virus replication. NS1 also binds to and inhibits the antiviral protein kinase PKR.
  • Cellular localization

    host cell cytoplasm and nucleus
  • Database links

    • Alternative names

      • Nonstructural protein 1 antibody
      • NS1 antibody
      • NS1A antibody

    References

    ab91642 has not yet been referenced specifically in any publications.

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