• Product name
    Anti-Influenza A Virus M2 Protein antibody
    See all Influenza A Virus M2 Protein primary antibodies
  • Description
    Rabbit polyclonal to Influenza A Virus M2 Protein
  • Host species
  • Tested applications
    Suitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Influenza A
  • Immunogen

    A synthetic peptide corresponding to N terminal residues of Influenza A Virus M2 Protein



Our Abpromise guarantee covers the use of ab56086 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notes
    ELISA: Use at an assay dependent dilution.
    WB: Use at an assay dependent concentration. Predicted molecular weight: 11 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Relevance
      The Matrix protein M2 forms a protons channel. When the environmental pH is lower than a threshold, the M2 channel is activated and selectively transports protons accross the membrane from the extracellular side to the cytoplasmic side. It is crucial for the uncoating process. When the virion is internalized into the endosome the channel can acidify the virion interior, promoting the dissociation of the viral matrix protein (M1) from the ribonucleoprotein (RNP) thus allowing the transport of the RNP from the virion into the cell’s nucleus. For some influenza virus subtypes, the M2 channel can elevate the intravesicular pH of the trans Golgi network, preventing the viral protein haemagglutinin, which is transported to the cell surface through the trans Golgi network, from incorrect maturation in an otherwise low pH environment.
    • Cellular localization
      Virion membrane. Apical cell membrane; Single-pass type III membrane protein.
    • Database links
      • Alternative names
        • Influenza A virus matrix protein M2 antibody
        • M antibody
        • M2 antibody
        • Matrix protein 2 antibody
        • Membrane ion channel M2 antibody
        • Membrane protein M2 antibody
        • Proton channel protein M2 antibody
        see all


      This product has been referenced in:
      • Sayhi M  et al. Electrochemical detection of influenza virus H9N2 based on both immunomagnetic extraction and gold catalysis using an immobilization-free screen printed carbon microelectrode. Biosens Bioelectron 107:170-177 (2018). Read more (PubMed: 29455027) »
      • Kawaguchi A  et al. Influenza Virus Induces Cholesterol-Enriched Endocytic Recycling Compartments for Budozone Formation via Cell Cycle-Independent Centrosome Maturation. PLoS Pathog 11:e1005284 (2015). Read more (PubMed: 26575487) »
      See all 5 Publications for this product

      Customer reviews and Q&As

      1-4 of 4 Abreviews or Q&A

      Abcam has not validated the combination of species/application used in this Abreview.
      A/Sw/SK/2001 (H1N1) influenza Purified protein (Purified inactivated human H3N2 influenza virus)
      Purified inactivated human H3N2 influenza virus

      Abcam user community

      Verified customer

      Submitted Nov 02 2016


      Thank you for your enquiry.

      The immunogens used to produce ab94925 and ab56086 consist of a small 15-20 amino acid peptide from Influenza A virus M2 protein. These peptides are not His tagged.

      I hope this is helpful. Please contact me again if you have any further questions.

      Read More


      Thank you very much for your inquiry. I have contacted the laboratory for information on the ab5416. However the laboratory has not tested this antibody neither on your strain. I did a sequence alignement of the immunogen and your sequence. Please see the results below. Indeed, the alignement is very good. However as this is a monoclonal antibody, we do not know the epitope and can therefore not guarantee crossreactivity. http://www.ebi.ac.uk/Tools/services/web_clustalw2/toolresult.ebi?tool=clustalw2&jobId=clustalw2-I20111223-121219-0395-63524695-pg We do have two other antibodies against the Influenza A Virus M2 protein, the ab56086 and the ab94925. I have already done the alignement of the immunogen of ab56086 with your protein of interest. The overlapp is 100%. I would therefore expect that this antibody does recognize your protein as well. xxx I am checking with the laboratory for the alingment of ab94925 with your protein (http://www.uniprot.org/uniprot/A5GX42) and will get back to you. If the customer would like to test the ab56086 on the Jersey Strain, I would be pleased to provide also a testing discount (www.abcam.com/collaborationdiscount). Please let me know if you would like to know more about this testing discount. Please do not hesitate to contact me, should you or the customer have any other question or concern.

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      Thank you for contacting us. The species is not applicable for this product so the discount code can’t be given. However please inform customer for submitting an Abreview after using the product. I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.  

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